Transmembrane Channel-Like 3 (Tmc3) (6th Cytoplasmic Loop) antibody

Antigen: Transmembrane Channel-Like 3 (Tmc3)

Synonyms: 9030203A06

Binding Site: 6th Cytoplasmic Loop

Clonality: Polyclonal

Host: Rabbit

Reactivity: Mouse (Murine)

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN351047

Additional Information

Alternative name: transmembrane channel-like protein 3 (TMC3)

UniProt: Q7TQ69

Immunogen: A synthetic from the 6th cytoplasmic loop of mouse transmembrane channel-like protein 3 (TMC3) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Detected in most neuronal organs and also in some non-neuronal tissues. Also known as:transmembrane channel-like protein 3, Tmc3.

Specificity: Appears to be specific for TMC3.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Keresztes, Mutai, Heller: "TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins." in: BMC genomics, Vol. 4, Issue 1, pp. 24, 2003 (PubMed).

Kurima, Yang, Sorber et al.: "Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis." in: Genomics, Vol. 82, Issue 3, pp. 300-8, 2003 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).