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Transmembrane Channel-Like 6 (TMC6) (2nd Cytoplasmic Loop) antibody

Details for Product No. ABIN351053, Supplier: Log in to see
Antigen
  • D11Ertd204e
  • EV1
  • EVER1
  • ever1
  • EVIN1
  • LAK-4P
  • MGC83549
  • zgc:92610
Epitope
2nd Cytoplasmic Loop
28
15
3
2
2
1
1
1
1
Reactivity
Human
43
16
8
Host
Rabbit
45
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
41
31
19
9
3
2
1
Supplier
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Immunogen A synthetic peptide from the 2d cytoplasmic loop of human transmembrane channel-like protein 6 (TMC6, EVER1, Protein LAK-4, EVIN1) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for TMC6.
Purification Whole serum
Alternative Name TMC6 (TMC6 Antibody Abstract)
Background SUBCELLULAR LOCATION: Endoplasmic reticulum membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in placenta, prostate, testis, activated T-lymphocytes and lymphokine-activated killer (LAK) lymphocytes. DISEASE: Defects in TMC6 are a cause of epidermodysplasia verruciformis. It is a rare autosomal recessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses. Infection leads to persistent wart-like or macular lesions. Also known as: TMC6, EVER1, Epidermodysplasia verruciformis protein 1, Protein LAK-4, EVIN1.
Research Area Organelles
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006

Tate, Suzuki, Kishimoto, Mitsuya: "Novel mutations of EVER1/TMC6 gene in a Japanese patient with epidermodysplasia verruciformis." in: Journal of human genetics, Vol. 49, Issue 4, pp. 223-5, 2004

Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003

Kurima, Yang, Sorber, Griffith: "Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis." in: Genomics, Vol. 82, Issue 3, pp. 300-8, 2003

Ramoz, Rueda, Bouadjar, Montoya, Orth, Favre: "Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis." in: Nature genetics, Vol. 32, Issue 4, pp. 579-81, 2002