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Details for Product No. ABIN351053

Transmembrane Channel-Like 6 (TMC6) (Cytoplasmic Loop) antibody

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Antigen
Synonyms EV1, EVER1, EVIN1, LAK-4P, D11Ertd204e, zgc:92610, MGC83549, ever1
Epitope
»Alternatives Cytoplasmic Loop
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN351053
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the 2d cytoplasmic loop of human transmembrane channel-like protein 6 (TMC6, EVER1, Protein LAK-4, EVIN1) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for CATSPER3.
Purity whole serum
Alternative Name transmembrane channel-like protein 6 (TMC6, EVER1, Protein LAK-4, EVIN1)
Background SUBCELLULAR LOCATION: Endoplasmic reticulum membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in placenta, prostate, testis, activated T-lymphocytes and lymphokine-activated killer (LAK) lymphocytes. DISEASE: Defects in TMC6 are a cause of epidermodysplasia verruciformis. It is a rare autosomal recessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses. Infection leads to persistent wart-like or macular lesions. Also known as: TMC6, EVER1, Epidermodysplasia verruciformis protein 1, Protein LAK-4, EVIN1.
UniProt Q86XQ3
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
Ramoz, Rueda, Bouadjar et al.: "Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis." in: Nature genetics, Vol. 32, Issue 4, pp. 579-81, 2002 (PubMed).

Kurima, Yang, Sorber et al.: "Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis." in: Genomics, Vol. 82, Issue 3, pp. 300-8, 2003 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Tate, Suzuki, Kishimoto et al.: "Novel mutations of EVER1/TMC6 gene in a Japanese patient with epidermodysplasia verruciformis." in: Journal of human genetics, Vol. 49, Issue 4, pp. 223-5, 2004 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Alternatives for antigen "Transmembrane Channel-Like 6 (TMC6)", type "Antibodies"
Hosts (27)
Reactivities (26), (17), (9)
Applications (27), (18), (16), (8), (1)
Epitopes (11), (4), (3), (2), (1), (1), (1)
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