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TMC8 antibody (Transmembrane Channel-Like 8) (5th Cytoplasmic Loop)

Details for Product anti-TMC8 Antibody No. ABIN351058, Supplier: Log in to see
Antigen
  • EV2
  • EVER2
  • Ever2
  • EVIN2
  • mFLJ00400
Epitope
5th Cytoplasmic Loop
26
15
7
3
2
2
1
1
1
Reactivity
Human
60
31
30
Host
Rabbit
61
Clonality
Polyclonal
Conjugate
This TMC8 antibody is un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
45
31
14
11
9
2
2
Supplier
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Immunogen A synthetic peptide from the 5th cytoplasmic loop of human transmembrane channel-like protein 8 (TMC8, EVER2, EVIN2) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for TMC8.
Purification Whole serum
Alternative Name TMC8 (TMC8 Antibody Abstract)
Background SUBCELLULAR LOCATION: Endoplasmic reticulum membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in placenta, prostate and testis. DISEASE: Defects in TMC8 are a cause of epidermodysplasia verruciformis. It is a rare autosomal recessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses. Infection leads to persistent wart-like or macular lesions. Also known as: TMC8, Epidermodysplasia verruciformis protein 2, EVER2, EVIN2.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006

Kurima, Yang, Sorber, Griffith: "Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis." in: Genomics, Vol. 82, Issue 3, pp. 300-8, 2003

Ramoz, Rueda, Bouadjar, Montoya, Orth, Favre: "Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis." in: Nature genetics, Vol. 32, Issue 4, pp. 579-81, 2002