Transmembrane Channel-Like 8 (TMC8) (5th cytoplasmic loop) antibody

Antigen: Transmembrane Channel-Like 8 (TMC8)

Synonyms: EV2, EVER2, EVIN2, FLJ40668, FLJ43684, MGC40121, MGC102701, Ever2, FLJ00400, mFLJ00400

Epitope: 5th cytoplasmic loop

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN351058

Additional Information

Alternative name: transmembrane channel-like protein 8 (TMC8, EVER2, EVIN2) (5th cytoplasmic loop)

Swiss-Prot: Q8IU68

Immunogen: A synthetic peptide from the 5th cytoplasmic loop of human transmembrane channel-like protein 8 (TMC8, EVER2, EVIN2) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in placenta, prostate and testis. DISEASE: Defects in TMC8 are a cause of epidermodysplasia verruciformis. It is a rare autosomal recessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses. Infection leads to persistent wart-like or macular lesions. Also known as: TMC8, Epidermodysplasia verruciformis protein 2, EVER2, EVIN2.

Specificity: Appears to be specific for TMC8.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Ramoz, Rueda, Bouadjar et al.: "Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis." in: Nature genetics, Vol. 32, Issue 4, pp. 579-81, 2002 (PubMed).

Kurima, Yang, Sorber et al.: "Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis." in: Genomics, Vol. 82, Issue 3, pp. 300-8, 2003 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).