Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (Extracellular Domain) antibody

Details for Product No. ABIN351065
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Antigen
Synonyms trk, trka, TRKA, MTC, TRK, TRK1, Trk-A, p140-TrkA, C80751, Tkr, TrkA, Trk, CTRKA, trkA, CAPM1, CFTD, NEM1, OK/SW-cl.5, TM-5, TM3, TM30, TM30nm, TM5, TPMsk3, hscp30
Epitope
Extracellular Domain
(36), (23), (21), (18), (17), (16), (15), (15), (12), (12), (12), (12), (12), (12), (12), (12), (10), (9), (8), (7), (6), (5), (5), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Rat (Rattus), Mouse (Murine)
(304), (177), (170), (29), (29), (12), (12)
Host
Rabbit
(290), (29), (4), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(11), (10), (10), (7), (6), (6), (6), (6), (6), (6), (6), (6), (5), (5), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(193), (146), (65), (60), (42), (42), (34), (25), (16), (10), (3), (1)
Pubmed 8 references available
Quantity 500 μg
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Catalog No. ABIN351065
454.67 $
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Immunogen A synthetic peptide from the extracellular domain of rat TrkA conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse.
Isotype IgG
Specificity Specific for TrkA.
Alternative Name TrkA
Background Function: Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.
Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 which bridges NTRK1 to NGFR. Interacts with NGFR and ARMS. Can form a ternary complex with NGFR and ARMS and this complex is affected by the expression levels of ARMS. An increase in ARMS expression leads to a decreased association of NGFR and NTRK1.
Subcellular location: Cell membrane, Single-pass type I membrane protein. Note: Endocytosed to the endosomes upon treatment of cells with NGF.
Tissue specificity: Isoform Trka-II is primarily expressed in neuronal cells, isoform Trka-I is found in non-neuronal tissues. Also known as: High affinity nerve growth factor receptor, NTRK1, p140-TrkA, Trk-A, Neurotrophic tyrosine kinase receptor type 1, Slow nerve growth factor receptor.
Research Area Cancer
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Meakin, Suter, Drinkwater et al.: "The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 6, pp. 2374-8, 1992 (PubMed).

Barker, Lomen-Hoerth, Gensch et al.: "Tissue-specific alternative splicing generates two isoforms of the trkA receptor." in: The Journal of biological chemistry, Vol. 268, Issue 20, pp. 15150-7, 1993 (PubMed).

Qian, Riccio, Zhang et al.: "Identification and characterization of novel substrates of Trk receptors in developing neurons." in: Neuron, Vol. 21, Issue 5, pp. 1017-29, 1999 (PubMed).

Kong, Boulter, Weber et al.: "An evolutionarily conserved transmembrane protein that is a novel downstream target of neurotrophin and ephrin receptors." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 1, pp. 176-85, 2001 (PubMed).

Wooten, Seibenhener, Mamidipudi et al.: "The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor." in: The Journal of biological chemistry, Vol. 276, Issue 11, pp. 7709-12, 2001 (PubMed).

Geetha, Wooten: "Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signaling." in: The Journal of biological chemistry, Vol. 278, Issue 7, pp. 4730-9, 2003 (PubMed).

Aruevalo, Yano, Teng et al.: "A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein." in: The EMBO journal, Vol. 23, Issue 12, pp. 2358-68, 2004 (PubMed).

Chang, Arevalo, Chao: "Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein." in: Journal of neuroscience research, Vol. 78, Issue 2, pp. 186-92, 2004 (PubMed).

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