Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN351066

TrkA,TrkB, TrkC (High Affinity Nerve Growth Factor Receptor) (pTyr683), (pTyr684) antibody

Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

»Alternatives pTyr683, pTyr684
»Alternatives Rat (Rattus), Mouse (Murine), Human, Chicken, Zebrafish
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 8 references available
Catalog no. ABIN351066
Quantity 100 µL
454.67 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide to phospho Y683 & Y684 of rat TrkA (and the corresponding phosphorylated sequences in TrkB and TrkC) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in mouse, human, chicken and zebrafish. Additionally, the antigen shares ~90% identity with the corresponding phosphorylated sequences in TrkB and TrkC.
Specificity Appears to be specific for TrkA, TrkB, TrkC.
Purity whole serum
Background Function: Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.
Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 which bridges NTRK1 to NGFR. Interacts with NGFR and ARMS. Can form a ternary complex with NGFR and ARMS and this complex is affected by the expression levels of ARMS. An increase in ARMS expression leads to a decreased association of NGFR and NTRK1.
Subcellular location: Cell membrane, Single-pass type I membrane protein. Note: Endocytosed to the endosomes upon treatment of cells with NGF.
Tissue specificity: Isoform Trka-II is primarily expressed in neuronal cells, isoform Trka-I is found in non-neuronal tissues. Also known as: High affinity nerve growth factor receptor, NTRK1, p140-TrkA, Trk-A, Neurotrophic tyrosine kinase receptor type 1, Slow nerve growth factor receptor.
UniProt P35739
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. This antibody recognises also the corresponding phosphorylated sequences in TrkB and TrkC.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Meakin, Suter, Drinkwater et al.: "The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 6, pp. 2374-8, 1992 (PubMed).

Barker, Lomen-Hoerth, Gensch et al.: "Tissue-specific alternative splicing generates two isoforms of the trkA receptor." in: The Journal of biological chemistry, Vol. 268, Issue 20, pp. 15150-7, 1993 (PubMed).

Qian, Riccio, Zhang et al.: "Identification and characterization of novel substrates of Trk receptors in developing neurons." in: Neuron, Vol. 21, Issue 5, pp. 1017-29, 1999 (PubMed).

Kong, Boulter, Weber et al.: "An evolutionarily conserved transmembrane protein that is a novel downstream target of neurotrophin and ephrin receptors." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 1, pp. 176-85, 2001 (PubMed).

Wooten, Seibenhener, Mamidipudi et al.: "The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor." in: The Journal of biological chemistry, Vol. 276, Issue 11, pp. 7709-12, 2001 (PubMed).

Geetha, Wooten: "Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signaling." in: The Journal of biological chemistry, Vol. 278, Issue 7, pp. 4730-9, 2003 (PubMed).

Aruevalo, Yano, Teng et al.: "A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein." in: The EMBO journal, Vol. 23, Issue 12, pp. 2358-68, 2004 (PubMed).

Chang, Arevalo, Chao: "Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein." in: Journal of neuroscience research, Vol. 78, Issue 2, pp. 186-92, 2004 (PubMed).

Alternatives for antigen "TrkA,TrkB, TrkC (High Affinity Nerve Growth Factor Receptor)", type "Antibodies"
Hosts (3), (2)
Reactivities (5), (5), (5), (5), (3)
Applications (5), (5)
Epitopes (3), (3), (2)