TRKB antibody (Extracellular Domain)

Catalog No. ABIN351075

Product Details anti-TRKB Antibody

Target: TRKB (NTRK2) (Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2))

Binding Specificity: AA 400-450, Extracellular Domain

Reactivity: Mouse

Host: Sheep

Clonality: Polyclonal

Conjugate: This TRKB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: Specific for TrkB.

Cross-Reactivity: Mouse, Rat

Cross-Reactivity (Details): Other species not yet tested.

Purification: IgG

Immunogen: A synthetic peptide from AA 400-450 of the extracellular domain of mouse TrkB conjugated to blue carrier protein was used as the antigen.

Isotype: IgG

Application Details

Application Notes: IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.

Handling Advice: Avoid freeze and thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date: 12 months

Target Details for TRKB

Target: TRKB (NTRK2) (Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2))

Alternative Name: TrkB (NTRK2 Products)

Synonyms: trkb antibody, trkb-b antibody, xtrkb antibody, si:ch211-220b11.1 antibody, trkB2 antibody, NTRK2 antibody, ntrk2 antibody, gp145-trkb antibody, TRKB antibody, GP145-TrkB antibody, trk-B antibody, AI848316 antibody, C030027L06Rik antibody, Tkrb antibody, trkB antibody, RATTRKB1 antibody, TRKB1 antibody, Trk-B antibody, TrkB antibody, neurotrophic receptor tyrosine kinase 2 antibody, neurotrophic receptor tyrosine kinase 2 L homeolog antibody, neurotrophic tyrosine kinase, receptor, type 2b antibody, neurotrophic receptor tyrosine kinase 2 S homeolog antibody, neurotrophic tyrosine kinase, receptor, type 2 antibody, NTRK2 antibody, ntrk2.L antibody, ntrk2b antibody, ntrk2.S antibody, ntrk2 antibody, Ntrk2 antibody

Background: FUNCTION: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and ARMS. SUBCELLULAR LOCATION: Membrane, Single-pass type I membrane protein.,Neurotrophic Receptors,Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, GP145-TrkB/GP95-TrkB, Trk-B, BDNF/NT-3 growth factors receptor

UniProt: Q63604

Pathways: RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Skeletal Muscle Fiber Development, Feeding Behaviour, Dicarboxylic Acid Transport