TRKB antibody (Neurotrophic Tyrosine Kinase, Receptor, Type 2) (Extracellular Domain)

Details for Product anti-NTRK2 Antibody No. ABIN351078, Supplier: Log in to see
Antigen
  • trkb
  • trkb-b
  • xtrkb
  • si:ch211-220b11.1
  • trkB2
  • NTRK2
  • ntrk2
  • gp145-trkb
  • TRKB
  • GP145-TrkB
  • trk-B
  • AI848316
  • C030027L06Rik
  • Tkrb
  • trkB
  • RATTRKB1
  • TRKB1
  • Trk-B
  • TrkB
  • neurotrophic tyrosine kinase, receptor, type 2
  • neurotrophic tyrosine kinase, receptor, type 2b
  • NTRK2
  • ntrk2-b
  • ntrk2b
  • ntrk2-a
  • ntrk2
  • Ntrk2
Alternatives
anti-Chicken TRKB antibody for Immunofluorescence
Epitope
Extracellular Domain, AA 400-450
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Reactivity
Rat (Rattus), Mouse (Murine)
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Host
Rabbit
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Clonality
Polyclonal
Conjugate
This TRKB antibody is un-conjugated
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Application
Immunohistochemistry (IHC), Western Blotting (WB)
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Options
Supplier
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Immunogen A synthetic peptide from aa region 400-450 of the extracellular domain of mouse TrkB conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for TrkB.
Purification Whole serum
Alternative Name TrkB (NTRK2 Antibody Abstract)
Background Function: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.
Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and ARMS.
Subcellular location: Membrane, Single-pass type I membrane protein. Also known as: Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, GP145-TrkB/GP95-TrkB, Trk-B, BDNF/NT-3 growth factors receptor.
Research Area Cancer
Pathways RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Skeletal Muscle Fiber Development, Feeding Behaviour, Dicarboxylic Acid Transport
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Ballif, Carey, Sunyaev, Gygi: "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." in: Journal of proteome research, Vol. 7, Issue 1, pp. 311-8, 2008 (PubMed).

Carninci, Kasukawa, Katayama, Gough, Frith, Maeda, Oyama, Ravasi, Lenhard, Wells, Kodzius, Shimokawa, Bajic, Brenner, Batalov, Forrest, Zavolan, Davis, Wilming, Aidinis, Allen, Ambesi-Impiombato et al.: "The transcriptional landscape of the mammalian genome. ..." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Ninkina, Grashchuck, Buchman, Davies: "TrkB variants with deletions in the leucine-rich motifs of the extracellular domain." in: The Journal of biological chemistry, Vol. 272, Issue 20, pp. 13019-25, 1997 (PubMed).

Soppet, Escandon, Maragos, Middlemas, Reid, Blair, Burton, Stanton, Kaplan, Hunter, Nikolics, Parada: "The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor." in: Cell, Vol. 65, Issue 5, pp. 895-903, 1991 (PubMed).

Klein, Conway, Parada, Barbacid: "The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain." in: Cell, Vol. 61, Issue 4, pp. 647-56, 1990 (PubMed).

Klein, Parada, Coulier, Barbacid: "trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development." in: The EMBO journal, Vol. 8, Issue 12, pp. 3701-9, 1990 (PubMed).

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