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Details for Product No. ABIN351082

Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (N-Term), (pTyr816) antibody

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Antigen
Synonyms GP145-TrkB, TRKB, trk-B, Tkrb, trkB, AI848316, C030027L06Rik, RATTRKB1, TRKB1, Trk-B, TrkB, trkb, trkb-b, xtrkb, si:ch211-220b11.1, trkB2, NTRK2, ntrk2, gp145-trkb
Epitope
»Alternatives N-Term, pTyr816
Reactivity
»Alternatives Human, Rat (Rattus), Mouse (Murine)
Host
»Alternatives Sheep
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 6 references available
Catalog no. ABIN351082
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the region around (and including) phospho Y816 site of human TrkB (BDNF/NT-3 growth factors receptor, TrkB tyrosine kinase, Trk-B) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse.
Isotype IgG
Specificity Appears to be specific for TrkB.
Purity IgG
Alternative Name TrkB (BDNF/NT-3 growth factors receptor,TrkB tyrosine kinase, Trk-B)
Background Function: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.
Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and ARMS.
Subcellular location: Membrane, Single-pass type I membrane protein. Also known as: Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, GP145-TrkB/GP95-TrkB, Trk-B, BDNF/NT-3 growth factors receptor.
UniProt Q16620
Application Notes IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. This antibody is also likely to recognise the unphosphorylated form.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Soppet, Escandon, Maragos et al.: "The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor." in: Cell, Vol. 65, Issue 5, pp. 895-903, 1991 (PubMed).

Klein, Conway, Parada et al.: "The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain." in: Cell, Vol. 61, Issue 4, pp. 647-56, 1990 (PubMed).

Klein, Parada, Coulier et al.: "trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development." in: The EMBO journal, Vol. 8, Issue 12, pp. 3701-9, 1990 (PubMed).

Ninkina, Grashchuck, Buchman et al.: "TrkB variants with deletions in the leucine-rich motifs of the extracellular domain." in: The Journal of biological chemistry, Vol. 272, Issue 20, pp. 13019-25, 1997 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Ballif, Carey, Sunyaev et al.: "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." in: Journal of proteome research, Vol. 7, Issue 1, pp. 311-8, 2008 (PubMed).

Alternatives for antigen "Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2)", type "Antibodies"
Hosts (179), (13), (6), (4), (4)
Reactivities (175), (148), (144), (27), (25), (24), (12), (1)
Applications (134), (67), (62), (40), (39), (26), (8), (8), (5), (4), (2), (2), (1)
Conjugates (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Epitopes (29), (29), (17), (14), (13), (6), (6), (5), (5), (5), (4), (4), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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