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NTRK3 antibody (Neurotrophic tyrosine Kinase, Receptor, Type 3) (Extracellular Domain)

Details for Product anti-NTRK3 Antibody No. ABIN351087, Supplier: Log in to see
Antigen
  • TRKC
  • gp145(trkC)
  • AW125844
  • Ntrk3_tv3
  • TrkC
  • trkC
Alternatives
anti-Human NTRK3 antibody for Immunohistochemistry
Epitope
Extracellular Domain
44
15
14
11
8
6
6
6
5
4
4
4
3
3
3
2
2
2
1
1
1
1
1
1
1
Reactivity
Rat (Rattus), Mouse (Murine), Human
129
57
37
4
2
2
1
1
1
1
Host
Rabbit
105
40
10
6
2
Clonality
Polyclonal
Conjugate
This NTRK3 antibody is un-conjugated
7
4
4
4
4
4
1
Application
Immunohistochemistry (IHC)
130
77
70
15
8
5
1
1
1
Supplier
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Immunogen A synthetic peptide from the extracellular domain of rat TrkC conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in mouse and human.
Isotype IgG
Specificity Specific for TrkC.
Alternative Name TrkC (NTRK3 Antibody Abstract)
Background Function: Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.
Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and ARMS.
Subcellular location: Membrane, Single-pass type I membrane protein.
Tissue specificity: Widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. Also known as: Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, GP145-TrkC, Trk-C, NT-3 growth factor receptor, NTRK3.
Research Area Cancer
Pathways RTK Signaling, Neurotrophin Signaling Pathway
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Ballif, Carey, Sunyaev et al.: "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." in: Journal of proteome research, Vol. 7, Issue 1, pp. 311-8, 2008 (PubMed).

Ultsch, Wiesmann, Simmons et al.: "Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC." in: Journal of molecular biology, Vol. 290, Issue 1, pp. 149-59, 1999 (PubMed).

Qian, Riccio, Zhang et al.: "Identification and characterization of novel substrates of Trk receptors in developing neurons." in: Neuron, Vol. 21, Issue 5, pp. 1017-29, 1999 (PubMed).

Tsoulfas, Soppet, Escandon et al.: "The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells." in: Neuron, Vol. 10, Issue 5, pp. 975-90, 1993 (PubMed).

Valenzuela, Maisonpierre, Glass et al.: "Alternative forms of rat TrkC with different functional capabilities." in: Neuron, Vol. 10, Issue 5, pp. 963-74, 1993 (PubMed).

Shelton, Sutherland, Gripp et al.: "Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 15, Issue 1 Pt 2, pp. 477-91, 1995 (PubMed).

McGregor, Baylin, Griffin et al.: "Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant." in: Genomics, Vol. 22, Issue 2, pp. 267-72, 1995 (PubMed).

Merlio, Ernfors, Jaber et al.: "Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system." in: Neuroscience, Vol. 51, Issue 3, pp. 513-32, 1993 (PubMed).