anti-TRPA1 antibody (Transient Receptor Potential Cation Channel, Subfamily A, Member 1) (1st Cytoplasmic Domain)

Details for Product anti-TRPA1 Antibody No. ABIN351096
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Antigen
Synonyms trpa1, ANKTM1, Anktm1, CG5751, CG5761, CT18073, DmTRPA1, Dmel\\CG5751, TRPA, TRPA1, TrpA, dANKTM1, dTRPA, dTRPA1, dTrpA, dTrpA1, dtrpA1, trpA1, GLEAN_02449, FEPS
Epitope
1st Cytoplasmic Domain
(15), (8), (7), (6), (5), (5), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Rat (Rattus)
(53), (14), (9), (4), (4), (2), (2), (1)
Host
Rabbit
(63), (6), (4)
Clonality
Polyclonal
Conjugate
This TRPA1 antibody is un-conjugated
(1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(58), (39), (15), (9), (2), (2), (2), (1), (1), (1), (1)
Pubmed 2 references available
Quantity 100 μL
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Immunogen A synthetic peptide from the 1t cytoplasmic domain of rat TRPA1 (ANKTM1) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for TRPA1.
Purification Whole serum
Alternative Name TRPA1 (TRPA1 Antibody Abstract)
Background The structure of the protein encoded by this gene is highly related to both the protein ankyrin andtransmembrane proteins. The specific function of this protein has not yet been determined, however, studies indicate the function may involve a role in signal transduction and growth control.
Tissue specificity: Expressed in inner ear. In inner ear, it is found in the distal half of stereocilia, along the length of the kinocilium and at high level in the pericuticular zone (at protein level). Specifically expressed in a subset of nociceptive neurons. Expressed in the same neurons that TRPV1. In contrast, it is not expressed in neurons expressing TRPM8. Expressed in the superior cervical ganglion.
Developmental stage: During utricle development, it is first expressed at E15 and E16 and peaks at E17. It drops at E18 but increases again at E19, possibly corresponding to a second wave of hair cells that are generated at E15. Inhibited by ruthenium red, a potent blocker of TRPV channels. Also known as: Transient receptor potential cation channel subfamily A member 1, ankyrin-like withtransmembrane domains protein 1, transformation sensitive protein p120, ANKTM1.
Research Area Neurology
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Jordt, Bautista, Chuang et al.: "Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1." in: Nature, Vol. 427, Issue 6971, pp. 260-5, 2004 (PubMed).

Story, Peier, Reeve et al.: "ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures." in: Cell, Vol. 112, Issue 6, pp. 819-29, 2003 (PubMed).

Validation Images
Catalog No. ABIN351096
454.67 $
Plus shipping costs $45.00
Quantity
Price
100 μL
454.67 $

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