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Details for Product No. ABIN351118

Transient Receptor Potential Cation Channel, Subfamily C, Member 1 (TRPC1) (2nd Extracellular Loop) antibody

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Antigen
Synonyms HTRP-1, TRP1, Trp1, Mtrp1, Trrp1, xtrpc1, Trpc1
Epitope
»Alternatives 2nd Extracellular Loop
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN351118
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the 2d extracellular loop of human TRPC1 conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse.
Isotype IgG
Specificity Appears to be specific for TRPC1.
Purity IgG
Alternative Name TRPC1
Background Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.
Subunit: Interacts with TRPC3. Interacts with ITPR3.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Seems to be ubiquitous. Also known as: Short transient receptor potential channel 1, TrpC1, TRP-1 protein, Trp1, Trrp1, Trpc1 transient receptor potential cation channel, subfamily C, member 1, Mtrp1, Trp-related protein 1.
UniProt Q9QX01
Application Notes IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Wes, Chevesich, Jeromin et al.: "TRPC1, a human homolog of a Drosophila store-operated channel." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 21, pp. 9652-6, 1995 (PubMed).

Zhu, Chu, Peyton et al.: "Molecular cloning of a widely expressed human homologue for the Drosophila trp gene." in: FEBS letters, Vol. 373, Issue 3, pp. 193-8, 1995 (PubMed).

Zitt, Zobel, Obukhov et al.: "Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion." in: Neuron, Vol. 16, Issue 6, pp. 1189-96, 1996 (PubMed).

Wang, OConnell, Dykeman et al.: "Cloning of Trp1beta isoform from rat brain: immunodetection and localization of the endogenous Trp1 protein." in: The American journal of physiology, Vol. 276, Issue 4 Pt 1, pp. C969-79, 1999 (PubMed).

Lockwich, Liu, Singh et al.: "Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains." in: The Journal of biological chemistry, Vol. 275, Issue 16, pp. 11934-42, 2000 (PubMed).

Alternatives for antigen "Transient Receptor Potential Cation Channel, Subfamily C, Member 1 (TRPC1)", type "Antibodies"
Hosts (34), (5), (4), (3)
Reactivities (42), (21), (21), (13), (13), (13), (12), (1), (1)
Applications (31), (17), (15), (11), (10), (3), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (12), (3), (3), (2), (2), (2), (2), (1), (1), (1)
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