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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Transient Receptor Potential Cation Channel, Subfamily C, Member 1 (TRPC1) (2nd Extracellular Loop) antibody
|Synonyms||TRP1, HTRP-1, MGC133334, MGC133335, Trp1, Mtrp1, Trrp1, TRPC1, trpc1|
2nd Extracellular Loop
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
|Quantity||100 µl (Variants)|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Immunogen||A synthetic peptide from the 2d extracellular loop of human TRPC1 conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse.|
|Description||FUNCTION: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. SUBUNIT: Interacts with TRPC3. Interacts with ITPR3. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Seems to be ubiquitous. Also known as: Short transient receptor potential channel 1, TrpC1, TRP-1 protein, Trp1, Trrp1, Trpc1 transient receptor potential cation channel, subfamily C, member 1, Mtrp1, Trp-related protein 1.|
|Specificity||Appears to be specific for TRPC1.|
|Application Notes||IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Wes, Chevesich, Jeromin et al.: "TRPC1, a human homolog of a Drosophila store-operated channel." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 21, pp. 9652-6, 1995 (PubMed).
Zhu, Chu, Peyton et al.: "Molecular cloning of a widely expressed human homologue for the Drosophila trp gene." in: FEBS letters, Vol. 373, Issue 3, pp. 193-8, 1995 (PubMed).
Zitt, Zobel, Obukhov et al.: "Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion." in: Neuron, Vol. 16, Issue 6, pp. 1189-96, 1996 (PubMed).
Wang, OConnell, Dykeman et al.: "Cloning of Trp1beta isoform from rat brain: immunodetection and localization of the endogenous Trp1 protein." in: The American journal of physiology, Vol. 276, Issue 4 Pt 1, pp. C969-79, 1999 (PubMed).
Lockwich, Liu, Singh et al.: "Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains." in: The Journal of biological chemistry, Vol. 275, Issue 16, pp. 11934-42, 2000 (PubMed).
|Hosts||Rabbit (20), Sheep (3), Goat (2), Mouse (1)|
|Reactivities||Human (13), Mouse (Murine) (4), Rat (Rattus) (4), Fruit Fly (Drosophila melanogaster) (2), Xenopus laevis (1)|
|Applications||Western Blotting (WB) (23), Immunohistochemistry (IHC) (15), ELISA (7), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (5), Immunohistochemistry (Fixed) (IHC (fx)) (3), Immunostaining (ISt) (1)|
|Epitopes||2nd Extracellular Loop (3), 4th Cytoplasmic Loop (3), C-Term (3), 1st Cytoplasmic Loop (1), 2nd Extracellular Domain (1), Extracellular Domain (1), Internal Region (1), pSer982 (1)|