Transient Receptor Potential Cation Channel, Subfamily C, Member 1 (TRPC1) (Extracellular Loop), (AA 500-540) antibody

Details for Product No. ABIN351119
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Antigen
Synonyms xtrpc1, Trpc1, HTRP-1, TRP1, Mtrp1, Trp1, Trrp1, CAS2, CATB, GP75, OCA3, TRP, TYRP, b-PROTEIN
Epitope
Extracellular Loop, AA 500-540
(15), (8), (4), (3), (3), (3), (2), (2), (1), (1)
Reactivity
Rat (Rattus), Mouse (Murine), Human
(49), (24), (24), (13), (12), (12), (12), (1)
Host
Sheep
(39), (4), (3), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(36), (19), (16), (10), (6), (2), (1), (1)
Pubmed 5 references available
Quantity 100 μL
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Catalog No. ABIN351119
454.67 $
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Immunogen A synthetic peptide from aa region 500-540 of the 2d extracellular loop of human TRPC1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
Specificity Specific for TRPC1.
Purification Whole serum
Alternative Name TRPC1
Background Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.
Subunit: Interacts with TRPC3. Interacts with ITPR3.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Seems to be ubiquitous. Also known as: Short transient receptor potential channel 1, TrpC1, TRP-1 protein, Trp1, Trrp1, Trpc1 transient receptor potential cation channel, subfamily C, member 1, Mtrp1, Trp-related protein 1.
Research Area Cardiovascular, Hypertrophy
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Wes, Chevesich, Jeromin et al.: "TRPC1, a human homolog of a Drosophila store-operated channel." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 21, pp. 9652-6, 1995 (PubMed).

Zhu, Chu, Peyton et al.: "Molecular cloning of a widely expressed human homologue for the Drosophila trp gene." in: FEBS letters, Vol. 373, Issue 3, pp. 193-8, 1995 (PubMed).

Zitt, Zobel, Obukhov et al.: "Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion." in: Neuron, Vol. 16, Issue 6, pp. 1189-96, 1996 (PubMed).

Wang, OConnell, Dykeman et al.: "Cloning of Trp1beta isoform from rat brain: immunodetection and localization of the endogenous Trp1 protein." in: The American journal of physiology, Vol. 276, Issue 4 Pt 1, pp. C969-79, 1999 (PubMed).

Lockwich, Liu, Singh et al.: "Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains." in: The Journal of biological chemistry, Vol. 275, Issue 16, pp. 11934-42, 2000 (PubMed).

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