Transient Receptor Potential Cation Channel, Subfamily C, Member 2, Pseudogene (TRPC2) (4th Cytoplasmic Loop) antibody

Details for Product No. ABIN351129
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Synonyms SCE8.04c, trpC2, RS01769, 3010009O07Rik, AI115608, TRPC2a, TRPC2b, Trrp2, mTrp2, smTRPC2, trp2
4th Cytoplasmic Loop
(1), (1)
Mouse (Murine)
(3), (3), (3), (2)
(8), (2)
Immunohistochemistry (IHC), Western Blotting (WB)
(10), (9)
Pubmed 6 references available
Quantity 100 μL
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Catalog No. ABIN351129
454.67 $
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Immunogen A synthetic peptide from the 4th cytoplasmic loop of mouse TRPC2 conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for TRPC2.
Purification Whole serum
Alternative Name TRPC2
Background Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. May also be activated by intracellular calcium store depletion.
Subcellular location: Membrane, Multi-pass membrane protein (Probable). Also known as: Short transient receptor potential channel 2, mTrp2, Trp2, Trrp2, Trpc2, transient receptor potential cation channel, subfamily C, member 2, trp2, Trrp2, mTrp2, TRPC2a, TRPC2b, smTRPC2, AI115608, 3010009O07Rik.
Research Area Neurology
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Kimchi, Xu, Dulac: "A functional circuit underlying male sexual behaviour in the female mouse brain." in: Nature, Vol. 448, Issue 7157, pp. 1009-14, 2007 (PubMed).

Kelliher, Spehr, Li et al.: "Pheromonal recognition memory induced by TRPC2-independent vomeronasal sensing." in: The European journal of neuroscience, Vol. 23, Issue 12, pp. 3385-90, 2006 (PubMed).

Ramsey, Delling, Clapham: "An introduction to TRP channels." in: Annual review of physiology, Vol. 68, pp. 619-47, 2006 (PubMed).

Stamboulian, Moutin, Treves et al.: "Junctate, an inositol 1,4,5-triphosphate receptor associated protein, is present in rodent sperm and binds TRPC2 and TRPC5 but not TRPC1 channels." in: Developmental biology, Vol. 286, Issue 1, pp. 326-37, 2005 (PubMed).

Hofmann, Schaefer, Schultz et al.: "Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2." in: The Biochemical journal, Vol. 351, Issue Pt 1, pp. 115-22, 2001 (PubMed).

Vannier, Peyton, Boulay et al.: "Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca2+ entry channel." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 5, pp. 2060-4, 1999 (PubMed).

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