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Details for Product No. ABIN351131

Transient Receptor Potential Cation Channel, Subfamily C, Member 3, 6, 7 (TRPC3, 6, 7) (Cytoplasmic Loop) antibody

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Antigen
Synonyms TRPC3
Epitope
»Alternatives Cytoplasmic Loop
Reactivity
»Alternatives Human, Rat (Rattus), Mouse (Murine)
Host
»Alternatives Sheep
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 8 references available
Catalog no. ABIN351131
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the 1t cytoplasmic loop of human TRPC3 conjugated to an immunogenic carrier protein was used as the antigen. The antigen shares 85% identity with TRPC6 and TRPC7.
Isotype IgG
Specificity Specific for Actin.
Purity whole serum
Alternative Name TRPC3, 6, 7
Background Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol-1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Abundantly expressed in brain. Concentrated in cerebellar Purkinje cells and sparsely localized in cerebellar granule lyer, pontine nuclei and thalamus. Lower levels detected in other tissues. Also known as: Short transient receptor potential channel 3, TrpC3, Htrp-3, trp3, transient receptor potential cation channel, subfamily C, member 3.
UniProt P63259
Research Area Cancer, Apoptosis/Necrosis, Cytoskeleton, Microfilaments, Extracellular Matrix
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
Wes, Chevesich, Jeromin et al.: "TRPC1, a human homolog of a Drosophila store-operated channel." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 21, pp. 9652-6, 1995 (PubMed).

Zhu, Jiang, Peyton et al.: "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry." in: Cell, Vol. 85, Issue 5, pp. 661-71, 1996 (PubMed).

Xu, Li, Guggino et al.: "Coassembly of TRP and TRPL produces a distinct store-operated conductance." in: Cell, Vol. 89, Issue 7, pp. 1155-64, 1997 (PubMed).

Zhu, Jiang, Birnbaumer: "Receptor-activated Ca2+ influx via human Trp3 stably expressed in human embryonic kidney (HEK)293 cells. Evidence for a non-capacitative Ca2+ entry." in: The Journal of biological chemistry, Vol. 273, Issue 1, pp. 133-42, 1998 (PubMed).

Vannier, Zhu, Brown et al.: "The membrane topology of human transient receptor potential 3 as inferred from glycosylation-scanning mutagenesis and epitope immunocytochemistry." in: The Journal of biological chemistry, Vol. 273, Issue 15, pp. 8675-9, 1998 (PubMed).

Kiselyov, Xu, Mozhayeva et al.: "Functional interaction between InsP3 receptors and store-operated Htrp3 channels." in: Nature, Vol. 396, Issue 6710, pp. 478-82, 1998 (PubMed).

Hofmann, Obukhov, Schaefer et al.: "Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol." in: Nature, Vol. 397, Issue 6716, pp. 259-63, 1999 (PubMed).

Boulay, Brown, Qin et al.: "Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 26, pp. 14955-60, 2000 (PubMed).

Alternatives for antigen "Transient Receptor Potential Cation Channel, Subfamily C, Member 3, 6, 7 (TRPC3, 6, 7)", type "Antibodies"
Hosts (7)
Reactivities (3), (3), (3)
Applications (7), (7)
Epitopes (2), (2), (2), (1)
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