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Details for Product No. ABIN351133

Transient Receptor Potential Cation Channel, Subfamily C, Member 3, 6, 7 (TRPC3, 6, 7) (Cytoplasmic Loop) antibody

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Antigen
Synonyms TRPC3
Epitope
»Alternatives Cytoplasmic Loop
Reactivity
»Alternatives Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 6 references available
Catalog no. ABIN351133
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the 4th cytoplasmic loop of mouse TRPC3 conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Appears to recognise TRPC3, TRPC6 and TRPC7.
Purity whole serum
Alternative Name TRPC3, 6, 7
Background Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol-1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Abundantly expressed in brain. Concentrated in cerebellar Purkinje cells and sparsely localized in cerebellar granule lyer, pontine nuclei and thalamus. Lower levels detected in other tissues. Also known as: Short transient receptor potential channel 3, transient receptor potential cation channel, subfamily C, member 3, TrpC3, Transient receptor protein 3, Mtrp3, Receptor-activated cation channel TRP3, Trp-related protein 3, Trrp3, MGC124333.
UniProt Q9QZC1
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Zhu, Jiang, Peyton et al.: "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry." in: Cell, Vol. 85, Issue 5, pp. 661-71, 1996 (PubMed).

Mori, Takada, Okada et al.: "Differential distribution of TRP Ca2+ channel isoforms in mouse brain." in: Neuroreport, Vol. 9, Issue 3, pp. 507-15, 1998 (PubMed).

Ohki, Miyoshi, Murata et al.: "A calcium-activated cation current by an alternatively spliced form of Trp3 in the heart." in: The Journal of biological chemistry, Vol. 275, Issue 50, pp. 39055-60, 2001 (PubMed).

Ramsey, Delling, Clapham: "An introduction to TRP channels." in: Annual review of physiology, Vol. 68, pp. 619-47, 2006 (PubMed).

Lee, Cherednichenko, Pessah et al.: "Functional coupling between TRPC3 and RyR1 regulates the expressions of key triadic proteins." in: The Journal of biological chemistry, Vol. 281, Issue 15, pp. 10042-8, 2006 (PubMed).

Rodruiguez-Santiago, Mendoza-Torres, Jimuenez-Bremont et al.: "Knockout of the trcp3 gene causes a recessive neuromotor disease in mice." in: Biochemical and biophysical research communications, Vol. 360, Issue 4, pp. 874-9, 2007 (PubMed).

Alternatives for antigen "Transient Receptor Potential Cation Channel, Subfamily C, Member 3, 6, 7 (TRPC3, 6, 7)", type "Antibodies"
Hosts (4), (3)
Reactivities (3), (2), (1)
Applications (7), (7)
Epitopes (4), (1), (1), (1)
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