Transient Receptor Potential Cation Channel, Subfamily C, Member 3, 6, 7 (TRPC3, 6, 7) (Cytoplasmic Loop) antibody

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  • TRPC3
  • transient receptor potential cation channel, subfamily C, member 3
  • TRPC3
  • trpc3
Cytoplasmic Loop
Mouse (Murine)
Immunohistochemistry (IHC), Western Blotting (WB)
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Immunogen A synthetic peptide from cytoplasmic loop of mouse TRPC3 conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Appears to recognise TRPC3, TRPC6 and TRPC7.
Purification Whole serum
Alternative Name TRPC3, 6, 7
Background Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol-1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Abundantly expressed in brain. Concentrated in cerebellar Purkinje cells and sparsely localized in cerebellar granule lyer, pontine nuclei and thalamus. Lower levels detected in other tissues. Also known as: Short transient receptor potential channel 3, transient receptor potential cation channel, subfamily C, member 3, TrpC3, Transient receptor protein 3, Mtrp3, Receptor-activated cation channel TRP3, Trp-related protein 3, Trrp3, MGC124333.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Rodruiguez-Santiago, Mendoza-Torres, Jimuenez-Bremont, Luopez-Revilla: "Knockout of the trcp3 gene causes a recessive neuromotor disease in mice." in: Biochemical and biophysical research communications, Vol. 360, Issue 4, pp. 874-9, 2007 (PubMed).

Lee, Cherednichenko, Pessah, Allen: "Functional coupling between TRPC3 and RyR1 regulates the expressions of key triadic proteins." in: The Journal of biological chemistry, Vol. 281, Issue 15, pp. 10042-8, 2006 (PubMed).

Ramsey, Delling, Clapham: "An introduction to TRP channels." in: Annual review of physiology, Vol. 68, pp. 619-47, 2006 (PubMed).

Ohki, Miyoshi, Murata, Ishibashi, Imai, Suzuki: "A calcium-activated cation current by an alternatively spliced form of Trp3 in the heart." in: The Journal of biological chemistry, Vol. 275, Issue 50, pp. 39055-60, 2001 (PubMed).

Mori, Takada, Okada, Wakamori, Imoto, Wanifuchi, Oka, Oba, Ikenaka, Kurosaki: "Differential distribution of TRP Ca2+ channel isoforms in mouse brain." in: Neuroreport, Vol. 9, Issue 3, pp. 507-15, 1998 (PubMed).

Zhu, Jiang, Peyton, Boulay, Hurst, Stefani, Birnbaumer: "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry." in: Cell, Vol. 85, Issue 5, pp. 661-71, 1996 (PubMed).

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