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Transient Receptor Potential Cation Channel, Subfamily C, Member 4 (TRPC4) (4th Cytoplasmic Loop) antibody

Details for Product No. ABIN351144, Supplier: Log in to see
Antigen
  • TRPC5
  • TRPC4
  • HTRP-4
  • HTRP4
  • TRP4
  • CCE1
  • STRPC4
  • Trp4
  • Trrp4
Epitope
4th Cytoplasmic Loop
38
32
16
6
3
2
2
2
1
1
1
1
Reactivity
Human
75
73
41
4
4
3
2
Host
Rabbit
49
45
18
3
Clonality
Polyclonal
Conjugate
Un-conjugated
5
5
5
5
5
4
2
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
109
41
40
39
36
33
8
2
2
1
1
1
Supplier
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Immunogen A synthetic peptide from the 4th cytoplasmic loop of human TRPC4 (TRP4, alpha, beta, gamma isoforms) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for TRPC4.
Purification Whole serum
Alternative Name TRPC4 (TRPC4 Antibody Abstract)
Background Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion.
Tissue specificity: Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain. Also known as: Short transient receptor potential channel 4, TrpC4, Trp4, Capacitative calcium entry channel 1, CCE1, Trrp4, Receptor-activated cation channel TRP4, Trp-related protein 4, hTrp-4, hTrp4.
Research Area Signaling, Tyrosine Kinases
Pathways
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers. ..." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).

Schaefer, Plant, Stresow et al.: "Functional differences between TRPC4 splice variants." in: The Journal of biological chemistry, Vol. 277, Issue 5, pp. 3752-9, 2002 (PubMed).

Mery, Magnino, Schmidt et al.: "Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors." in: FEBS letters, Vol. 487, Issue 3, pp. 377-83, 2001 (PubMed).

McKay, Szymeczek-Seay, Lievremont et al.: "Cloning and expression of the human transient receptor potential 4 (TRP4) gene: localization and functional expression of human TRP4 and TRP3." in: The Biochemical journal, Vol. 351 Pt 3, pp. 735-46, 2001 (PubMed).

Zhu, Jiang, Peyton et al.: "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry." in: Cell, Vol. 85, Issue 5, pp. 661-71, 1996 (PubMed).

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