Transient Receptor Potential Cation Channel, Subfamily C, Member 4 (TRPC4) (C-Term), (4th Cytoplasmic Loop) antibody

Details for Product No. ABIN351144
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

 
Antigen
Synonyms HTRP-4, HTRP4, TRP4, CCE1, Trp4, Trrp4, STRPC4, TRPC5, TRPC4, Trpc4
Epitope
C-Term, 4th Cytoplasmic Loop
(9), (4), (4), (3), (3), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(24), (20), (15), (2), (2), (2), (1), (1), (1)
Host
Rabbit
(22), (8), (6), (1)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(34), (13), (8), (6), (6), (5), (3), (2), (1), (1)
Pubmed 6 references available
Catalog no. ABIN351144
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
Options
Shipping to United States (Change)
Availability Will be delivered in 7 to 8 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide from the c-terminal region of human TPC1 (Two pore calcium channel protein 1) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Specific for TPC1.
Purification whole serum
Alternative Name TRPC4
Background Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion.
Tissue specificity: Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain. Also known as: Short transient receptor potential channel 4, TrpC4, Trp4, Capacitative calcium entry channel 1, CCE1, Trrp4, Receptor-activated cation channel TRP4, Trp-related protein 4, hTrp-4, hTrp4.
UniProt Q9ULQ1
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Zhu, Jiang, Peyton et al.: "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry." in: Cell, Vol. 85, Issue 5, pp. 661-71, 1996 (PubMed).

McKay, Szymeczek-Seay, Lievremont et al.: "Cloning and expression of the human transient receptor potential 4 (TRP4) gene: localization and functional expression of human TRP4 and TRP3." in: The Biochemical journal, Vol. 351 Pt 3, pp. 735-46, 2001 (PubMed).

Mery, Magnino, Schmidt et al.: "Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors." in: FEBS letters, Vol. 487, Issue 3, pp. 377-83, 2001 (PubMed).

Schaefer, Plant, Stresow et al.: "Functional differences between TRPC4 splice variants." in: The Journal of biological chemistry, Vol. 277, Issue 5, pp. 3752-9, 2002 (PubMed).

Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Hosts (22), (8), (6), (1)
Reactivities (24), (20), (15), (2), (2), (2), (1), (1), (1)
Applications (34), (13), (8), (6), (6), (5), (3), (2), (1), (1)
Epitopes (9), (4), (4), (3), (3), (2), (2), (1), (1), (1), (1)
back to top