Transient Receptor Potential Cation Channel, Subfamily C, Member 5 (TRPC5) (4th Cytoplasmic Domain) antibody

Details for Product No. ABIN351153
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Antigen
Synonyms trpc5, wu:fi73f08, TRPC5, Trpc5, TRP5, CCE2, TRP-5, Trrp5, trp
Epitope
4th Cytoplasmic Domain
(20), (8), (7), (2), (2), (2), (1), (1), (1)
Reactivity
Human
(43), (8), (7), (3), (2), (1)
Host
Sheep
(29), (18), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(49), (36), (19), (19), (12), (4), (3), (2), (1), (1)
Pubmed 2 references available
Quantity 500 µg
Options
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Catalog No. ABIN351153
454.67 $
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Immunogen A synthetic peptide from 4th cytoplasmic domain of human TRPC5 (TRP5) conjugated to an immunogenic carrier protein was used as the immunogen.
Isotype IgG
Specificity Specific for TRPC5.
Alternative Name TRPC5
Background Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion.
Subunit: Interacts with NHERF.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in brain with higher levels in fetal brain. Also known as: Short transient receptor potential channel 5, TrpC5, Htrp-5, trp5, TRP5.
Research Area Signaling, Metabolism
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Sossey-Alaoui, Lyon, Jones et al.: "Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca2+ entry channel." in: Genomics, Vol. 60, Issue 3, pp. 330-40, 1999 (PubMed).

Ross, Grafham, Coffey et al.: "The DNA sequence of the human X chromosome. ..." in: Nature, Vol. 434, Issue 7031, pp. 325-37, 2005 (PubMed).

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