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Transient Receptor Potential Cation Channel, Subfamily C, Member 5 (TRPC5) (4th Cytoplasmic Loop) antibody

Details for Product No. ABIN351157, Supplier: Log in to see
Antigen
  • trpc5
  • wu:fi73f08
  • TRPC5
  • Trpc5
  • TRP5
  • CCE2
  • TRP-5
  • Trrp5
  • trp
Epitope
4th Cytoplasmic Loop
37
16
14
3
2
2
2
2
2
1
1
1
1
Reactivity
Human, Rat (Rattus), Mouse (Murine)
75
26
24
3
2
1
Host
Sheep
48
31
3
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
79
60
36
20
19
4
4
2
1
1
Supplier
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Immunogen A synthetic peptide from the 4th cytoplasmic loop of human TRPC5 (TRP5, Htrp-5, Htrp5) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat, mouse and rabbit.
Specificity Specific for TRPC5.
Purification Whole serum
Alternative Name TRPC5 (TRPC5 Antibody Abstract)
Background Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion.
Subunit: Interacts with NHERF.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in brain with higher levels in fetal brain. Also known as: Short transient receptor potential channel 5, TrpC5, Htrp-5, trp5, TRP5.
Research Area Signaling, Metabolism
Pathways
Application Notes A dilution of 1 : 300 to 1 : 3000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Ross, Grafham, Coffey et al.: "The DNA sequence of the human X chromosome. ..." in: Nature, Vol. 434, Issue 7031, pp. 325-37, 2005 (PubMed).

Obukhov, Nowycky: "TRPC5 activation kinetics are modulated by the scaffolding protein ezrin/radixin/moesin-binding phosphoprotein-50 (EBP50)." in: Journal of cellular physiology, Vol. 201, Issue 2, pp. 227-35, 2004 (PubMed).

Tang, Tang, Chen et al.: "Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF." in: The Journal of biological chemistry, Vol. 275, Issue 48, pp. 37559-64, 2000 (PubMed).

Sossey-Alaoui, Lyon, Jones et al.: "Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca2+ entry channel." in: Genomics, Vol. 60, Issue 3, pp. 330-40, 1999 (PubMed).

Okada, Shimizu, Wakamori et al.: "Molecular cloning and functional characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain." in: The Journal of biological chemistry, Vol. 273, Issue 17, pp. 10279-87, 1998 (PubMed).

Zhu, Jiang, Peyton et al.: "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry." in: Cell, Vol. 85, Issue 5, pp. 661-71, 1996 (PubMed).

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