Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) antibody

Details for Product No. ABIN351160
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Antigen
Synonyms trpc6, FSGS2, TRP6, AV025995, LLHWJM002, LLHWJM003, LLHWJM004, TRP-6, Trrp6, mtrp6, trp6, bZ1P14.9, si:rp71-1p14.9
Reactivity
Mouse (Murine), Rat (Rattus)
(79), (58), (42), (19), (19), (19), (18), (4), (3), (1)
Host
Rabbit
(75), (13), (5), (2), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(73), (33), (26), (18), (13), (10), (2), (2), (1)
Pubmed 6 references available
Quantity 100 μL
Options
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Catalog No. ABIN351160
454.67 $
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Immunogen A synthetic peptide from taa region 10-60 of rat TRPC6 conjugated to an immunogenic carrier protein was used as the antigen. The antigen is homologous with the corresponding sequence in mouse.
Specificity Specific for TRPC6.
Purification Whole serum
Alternative Name TRPC6
Background Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Short transient receptor potential channel 6, TrpC6, Calcium entry channel, Trp6, transient receptor potential cation channel, subfamily C, member 6, Trrp6, mtrp6, AV025995, LLHWJM002, LLHWJM003, LLHWJM004.
Research Area Signaling
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Zhu, Jiang, Peyton et al.: "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry." in: Cell, Vol. 85, Issue 5, pp. 661-71, 1996 (PubMed).

Boulay, Zhu, Peyton et al.: "Cloning and expression of a novel mammalian homolog of Drosophila transient receptor potential (Trp) involved in calcium entry secondary to activation of receptors coupled by the Gq class of G protein." in: The Journal of biological chemistry, Vol. 272, Issue 47, pp. 29672-80, 1997 (PubMed).

Buess, Engler, Hirsch et al.: "Search for oncogenic regulators in an autocrine tumor model using differential display PCR: identification of novel candidate genes including the calcium channel mtrp6." in: Oncogene, Vol. 18, Issue 7, pp. 1487-94, 1999 (PubMed).

Ramsey, Delling, Clapham: "An introduction to TRP channels." in: Annual review of physiology, Vol. 68, pp. 619-47, 2006 (PubMed).

Weissmann, Dietrich, Fuchs et al.: "Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 50, pp. 19093-8, 2006 (PubMed).

Dietrich, Gudermann: "TRPC6." in: Handbook of experimental pharmacology, Issue 179, pp. 125-41, 2007 (PubMed).

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