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Details for Product No. ABIN351163

Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) (4th Cytoplasmic Loop) antibody

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Antigen
Synonyms FSGS2, TRP6, AV025995, LLHWJM002, LLHWJM003, LLHWJM004, TRP-6, Trrp6, mtrp6, trp6, bZ1P14.9, si:rp71-1p14.9, trpc6
Epitope
»Alternatives 4th Cytoplasmic Loop
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 6 references available
Catalog no. ABIN351163
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the 4th cytoplasmic loop of human TRPC6 conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Appears to be specific for TRPC6.
Purity whole serum
Alternative Name TRPC6
Background Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Short transient receptor potential channel 6, TRP6, transient receptor potential cation channel, subfamily C, member 6, TRP6, FSGS2, FLJ11098, FLJ14863.
UniProt Q9Y210
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 3000 is recommended. The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
DEsposito, Strazzullo, Cuccurese et al.: "Identification and assignment of the human transient receptor potential channel 6 gene TRPC6 to chromosome 11q21-->q22." in: Cytogenetics and cell genetics, Vol. 83, Issue 1-2, pp. 46-7, 1999 (PubMed).

Hofmann, Obukhov, Schaefer et al.: "Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol." in: Nature, Vol. 397, Issue 6716, pp. 259-63, 1999 (PubMed).

Philipp, Trost, Warnat et al.: "TRP4 (CCE1) protein is part of native calcium release-activated Ca2+-like channels in adrenal cells." in: The Journal of biological chemistry, Vol. 275, Issue 31, pp. 23965-72, 2000 (PubMed).

Winn, Conlon, Lynn et al.: "A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis." in: Science (New York, N.Y.), Vol. 308, Issue 5729, pp. 1801-4, 2005 (PubMed).

Reiser, Polu, Möller et al.: "TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function." in: Nature genetics, Vol. 37, Issue 7, pp. 739-44, 2005 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Alternatives for antigen "Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6)", type "Antibodies"
Hosts (75), (13), (5), (1), (1)
Reactivities (72), (56), (43), (19), (19), (19), (17), (4), (4), (1)
Applications (70), (34), (23), (18), (16), (10), (2), (2), (2), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (24), (18), (3), (2), (1), (1), (1), (1), (1)
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