Transient Receptor Potential Cation Channel, Subfamily M, Member 1 (TRPM1) (2d cytoplasmic loop) antibody

Antigen: Transient Receptor Potential Cation Channel, Subfamily M, Member 1 (TRPM1)

Synonyms: MLSN1, LTRPC1, Mlsn1, Ltrpc1, AI606771, melastatin, 4732499L03Rik, zgc:158632

Epitope: 2d cytoplasmic loop

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN351183

Additional Information

Alternative name: TRPM1 (LTRPC1, MLSN1, melastatin-1) (2d cytoplasmic loop)

Swiss-Prot: O75560

Immunogen: A synthetic peptide from the 2d cytoplasmic loop of human TRPM1 (LTRPC1, MLSN1, melastatin-1) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: The protein encoded by this gene is similar to the transient receptor potential (Trp) calcium channel family members. The expression of this protein is inversely correlated with melanoma aggressiveness, suggesting that it suppresses melanoma metastasis. Also known as: Transient receptor potential cation channel subfamily M member 1, TRPM1, MLSN1, LTRPC1, melastatin-1, melastatin 1.

Specificity: Appears to be specific for TRPM1.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. This antibody works beautifully in paraffin sections. Heating the tissue sections above 85°C is not recommended.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Duncan, Deeds, Hunter et al.: "Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis." in: Cancer research, Vol. 58, Issue 7, pp. 1515-20, 1998 (PubMed).

Hunter, Shao, Smutko et al.: "Chromosomal localization and genomic characterization of the mouse melastatin gene (Mlsn1)." in: Genomics, Vol. 54, Issue 1, pp. 116-23, 1999 (PubMed).

Clapham, Julius, Montell et al.: "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels." in: Pharmacological reviews, Vol. 57, Issue 4, pp. 427-50, 2005 (PubMed).