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Transient Receptor Potential Cation Channel, Subfamily M, Member 1 (TRPM1) (AA 750-800) antibody

Details for Product No. ABIN351183, Supplier: Login to see
Antigen
  • TRPM1b
  • trpm1
  • zgc:158632
  • CSNB1C
  • LTRPC1
  • MLSN1
  • 4732499L03Rik
  • AI606771
  • Ltrpc1
  • Mlsn1
  • melastatin
Epitope
AA 750-800
3
1
1
1
Reactivity
Human
8
7
7
1
1
1
1
Host
Rabbit
10
4
Clonality
Polyclonal
Conjugate
Un-conjugated
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
12
11
3
1
Supplier
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Immunogen A synthetic peptide from aa region 750-800 of human TRPM1 conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for TRPM1.
Purification Whole serum
Alternative Name TRPM1 (TRPM1 Antibody Abstract)
Background The protein encoded by this gene is similar to the transient receptor potential (Trp) calcium channel family members. The expression of this protein is inversely correlated with melanoma aggressiveness, suggesting that it suppresses melanoma metastasis. Also known as: Transient receptor potential cation channel subfamily M member 1, TRPM1, MLSN1, LTRPC1, melastatin-1, melastatin 1.
Research Area Signaling, Metabolism
Pathways
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user. This antibody works beautifully in paraffin sections. Heating the tissue sections above 85°C is not recommended.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Clapham, Julius, Montell et al.: "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels." in: Pharmacological reviews, Vol. 57, Issue 4, pp. 427-50, 2005 (PubMed).

Hunter, Shao, Smutko et al.: "Chromosomal localization and genomic characterization of the mouse melastatin gene (Mlsn1)." in: Genomics, Vol. 54, Issue 1, pp. 116-23, 1999 (PubMed).

Duncan, Deeds, Hunter et al.: "Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis." in: Cancer research, Vol. 58, Issue 7, pp. 1515-20, 1998 (PubMed).

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