Transient Receptor Potential Cation Channel, Subfamily M, Member 1 (TRPM1) (4th Cytoplasmic Loop) antibody

Details for Product No. ABIN351185
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Antigen
Synonyms TRPM1b, trpm1, zgc:158632, CSNB1C, LTRPC1, MLSN1, 4732499L03Rik, AI606771, Ltrpc1, Mlsn1, melastatin
Epitope
4th Cytoplasmic Loop
(4), (1), (1)
Reactivity
Human
(5), (4), (4)
Host
Rabbit
(7), (4)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(11), (10), (1)
Pubmed 3 references available
Quantity 100 μL
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Catalog No. ABIN351185
454.67 $
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Immunogen A synthetic peptide from the 4th cytoplasmic loop of human TRPM1 (LTRPC1, MLSN1, melastatin-1) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Specific for TRPM1.
Purification Whole serum
Alternative Name TRPM1
Background The protein encoded by this gene is similar to the transient receptor potential (Trp) calcium channel family members. The expression of this protein is inversely correlated with melanoma aggressiveness, suggesting that it suppresses melanoma metastasis. Also known as: Transient receptor potential cation channel subfamily M member 1, TRPM1, MLSN1, LTRPC1, melastatin-1, melastatin 1.
Research Area Signaling, Metabolism
Application Notes A dilution of 1 : 300 to 1 : 3000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Duncan, Deeds, Hunter et al.: "Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis." in: Cancer research, Vol. 58, Issue 7, pp. 1515-20, 1998 (PubMed).

Hunter, Shao, Smutko et al.: "Chromosomal localization and genomic characterization of the mouse melastatin gene (Mlsn1)." in: Genomics, Vol. 54, Issue 1, pp. 116-23, 1999 (PubMed).

Clapham, Julius, Montell et al.: "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels." in: Pharmacological reviews, Vol. 57, Issue 4, pp. 427-50, 2005 (PubMed).

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