Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) (C-Term) antibody

Antigen: Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2)

Synonyms: KNP3, EREG1, TRPC7, LTRPC2, NUDT9H, NUDT9L1, MGC133383, Trpm2-predicted, TRPM2, Trp7, Trrp7, C79133, 9830168K16Rik

Epitope: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Rat (Rattus)

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN351189

Additional Information

Alternative name: TRPM2 (c-terminal region)

Swiss-Prot: Q2PH54

Immunogen: A synthetic peptide from c-terminal region of rat TRPM2 conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: TRPM2 belongs to ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6transmembrane helices in which the last two helices flank loop which determines ion selectivity. Also known as: Transient receptor potential melastatin family 2, Trpm2-predicted.

Specificity: Appears to be specific for TRPM2.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Kwitek, Gullings-Handley, Yu et al.: "High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence." in: Genome research, Vol. 14, Issue 4, pp. 750-7, 2004 (PubMed).

Fonfria, Marshall, Boyfield et al.: "Amyloid beta-peptide(1-42) and hydrogen peroxide-induced toxicity are mediated by TRPM2 in rat primary striatal cultures." in: Journal of neurochemistry, Vol. 95, Issue 3, pp. 715-23, 2005 (PubMed).

Fonfria, Mattei, Hill et al.: "TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated, and functionally expressed in C13 microglia." in: Journal of receptor and signal transduction research, Vol. 26, Issue 3, pp. 179-98, 2006 (PubMed).