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TRPM2 antibody (Transient Receptor Potential Cation Channel, Subfamily M, Member 2) (3rd Extracellular Loop)

Details for Product anti-TRPM2 Antibody No. ABIN351191, Supplier: Log in to see
Antigen
  • 9830168K16Rik
  • C79133
  • EREG1
  • KNP3
  • LTRPC2
  • NUDT9H
  • NUDT9L1
  • si:ch73-263b18.1
  • Trp7
  • TRPC7
  • TRPM2
  • Trpm2-predicted
  • Trrp7
Epitope
3rd Extracellular Loop
10
7
7
5
4
2
2
2
2
1
1
1
1
Reactivity
Human
32
25
22
2
Host
Rabbit
42
5
2
Clonality
Polyclonal
Conjugate
This TRPM2 antibody is un-conjugated
2
2
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
40
24
11
6
5
5
3
1
1
1
1
Supplier
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Immunogen A synthetic peptide from the 3d extracellular loop of human TRPM2 (TRPC7, LTRPC2) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for TRPM2.
Purification Whole serum
Alternative Name TRPM2 (TRPM2 Antibody Abstract)
Background The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Function: Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress.
Catalytic activity: ADP-ribose + H2O = AMP + D-ribose 5-phosphate.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Transient receptor potential cation channel subfamily M member 2, long transient receptor potential channel 2, LTrpC2, LTrpC-2, transient receptor potential channel 7, TrpC7, estrogen-responsive element-associated gene 1 protein, EREG1, KNP3, LTRPC2, TRPC7, KNP3, NUDT9H, NUDT9L1, MGC133383.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Zhang, Chu, Tong, Cheung, Conrad, Masker, Miller: "A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death." in: The Journal of biological chemistry, Vol. 278, Issue 18, pp. 16222-9, 2003

Hara, Wakamori, Ishii, Maeno, Nishida, Yoshida, Yamada, Shimizu, Mori, Kudoh, Shimizu, Kurose, Okada, Imoto, Mori: "LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death." in: Molecular cell, Vol. 9, Issue 1, pp. 163-73, 2002

Wehage, Eisfeld, Heiner, Juengling, Zitt, Lueckhoff: "Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose." in: The Journal of biological chemistry, Vol. 277, Issue 26, pp. 23150-6, 2002

Perraud, Fleig, Dunn, Bagley, Launay, Schmitz, Stokes, Zhu, Bessman, Penner, Kinet, Scharenberg: "ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology." in: Nature, Vol. 411, Issue 6837, pp. 595-9, 2001

Sano, Inamura, Miyake, Mochizuki, Yokoi, Matsushime, Furuichi: "Immunocyte Ca2+ influx system mediated by LTRPC2." in: Science (New York, N.Y.), Vol. 293, Issue 5533, pp. 1327-30, 2001

Hattori, Fujiyama, Taylor, Watanabe, Yada, Park, Toyoda, Ishii, Totoki, Choi, Groner, Soeda, Ohki, Takagi, Sakaki, Taudien, Blechschmidt, Polley, Menzel, Delabar, Kumpf, Lehmann, Patterson, Reichwald et al.: "The DNA sequence of human chromosome 21. ..." in: Nature, Vol. 405, Issue 6784, pp. 311-9, 2000

Nagamine, Kudoh, Minoshima, Kawasaki, Asakawa, Ito, Shimizu: "Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain." in: Genomics, Vol. 54, Issue 1, pp. 124-31, 1999

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