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Details for Product No. ABIN351196

Transient Receptor Potential Cation Channel, Subfamily M, Member 3 (TRPM3) (4th Cytoplasmic Loop) antibody

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Antigen
Synonyms GON-2, MLSN2, LTRPC3, AU018608, 9330180E14, 6330504P12Rik, B930001P07Rik
Epitope
»Alternatives 4th Cytoplasmic Loop
Reactivity
»Alternatives Human, Rat (Rattus), Mouse (Murine), Monkey, Dog (Canine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN351196
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the 4th cytoplasmic loop of human TRPM3 (Melastatin-2, LTrpC3, MLSN2, GON-2) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat, mouse, monkey and dog.
Specificity Appears to be specific for TRPM3.
Purity whole serum
Alternative Name TRPM3 (Melastatin-2, LTrpC3, MLSN2)
Background The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified.
Function: Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed primarily in the kidney and, at lower levels, in brain, testis, ovary, pancreas and spinal cord. Expression in the brain and kidney was determined at protein level. In the kidney, expressed predominantly in the collecting tubular epithelium in the medulla, medullary rays, and periglomerular regions, in the brain, highest levels are found in the cerebellum, choroid plexus, the locus coeruleus, the posterior thalamus and the substantia nigra. Down-regulated in renal tumors compared to normal kidney. Also known as: Transient receptor potential cation channel subfamily M member 3, long transient receptor potential channel 3, LTrpC3, Melastatin-2, MLSN2, LTRPC3, KIAA1616, GON-2.
UniProt Q9HCF6
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Nagase, Kikuno, Nakayama et al.: "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 7, Issue 4, pp. 273-81, 2000 (PubMed).

Grimm, Kraft, Sauerbruch et al.: "Molecular and functional characterization of the melastatin-related cation channel TRPM3." in: The Journal of biological chemistry, Vol. 278, Issue 24, pp. 21493-501, 2003 (PubMed).

Lee, Chen, Sun et al.: "Expression and characterization of human transient receptor potential melastatin 3 (hTRPM3)." in: The Journal of biological chemistry, Vol. 278, Issue 23, pp. 20890-7, 2003 (PubMed).

Humphray, Oliver, Hunt et al.: "DNA sequence and analysis of human chromosome 9." in: Nature, Vol. 429, Issue 6990, pp. 369-74, 2004 (PubMed).

Alternatives for antigen "Transient Receptor Potential Cation Channel, Subfamily M, Member 3 (TRPM3)", type "Antibodies"
Hosts (37), (2), (1)
Reactivities (31), (21), (19), (14), (13), (12), (5)
Applications (31), (12), (10), (9), (6), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (11), (2), (2), (2), (1)
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