Transient Receptor Potential Cation Channel, Subfamily M, Member 3 (TRPM3) (1st Extracellular Loop) antibody

Details for Product No. ABIN351199
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Antigen
Synonyms GON-2, LTRPC3, MLSN2, 6330504P12Rik, 9330180E14, AU018608, B930001P07Rik, si:dkey-201c13.4, trpm6
Epitope
1st Extracellular Loop
(14), (3), (2), (1), (1), (1)
Reactivity
Human
(37), (26), (23), (14), (14), (12), (3), (2)
Host
Sheep
(39), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(31), (14), (10), (7), (3), (1)
Pubmed 4 references available
Quantity 100 µL
Options
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Catalog No. ABIN351199
454.67 $
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Immunogen A synthetic peptide from 1t extracellular loop of human TRPM3 conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for TRPM3.
Purification Whole serum
Alternative Name TRPM3
Background The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified.
Function: Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed primarily in the kidney and, at lower levels, in brain, testis, ovary, pancreas and spinal cord. Expression in the brain and kidney was determined at protein level. In the kidney, expressed predominantly in the collecting tubular epithelium in the medulla, medullary rays, and periglomerular regions, in the brain, highest levels are found in the cerebellum, choroid plexus, the locus coeruleus, the posterior thalamus and the substantia nigra. Down-regulated in renal tumors compared to normal kidney. Also known as: Transient receptor potential cation channel subfamily M member 3, long transient receptor potential channel 3, LTrpC3, Melastatin-2, MLSN2, LTRPC3, KIAA1616, GON-2.
Research Area Signaling, Metabolism
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Nagase, Kikuno, Nakayama et al.: "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 7, Issue 4, pp. 273-81, 2000 (PubMed).

Grimm, Kraft, Sauerbruch et al.: "Molecular and functional characterization of the melastatin-related cation channel TRPM3." in: The Journal of biological chemistry, Vol. 278, Issue 24, pp. 21493-501, 2003 (PubMed).

Lee, Chen, Sun et al.: "Expression and characterization of human transient receptor potential melastatin 3 (hTRPM3)." in: The Journal of biological chemistry, Vol. 278, Issue 23, pp. 20890-7, 2003 (PubMed).

Humphray, Oliver, Hunt et al.: "DNA sequence and analysis of human chromosome 9. ..." in: Nature, Vol. 429, Issue 6990, pp. 369-74, 2004 (PubMed).

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