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Details for Product No. ABIN351203

Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4) antibody

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Synonyms 1110030C19Rik, AW047689, LTRPC4, LTrpC-4, TRPM4B, Mls2s, PFHB1B, trpm4, TRPM4
»Alternatives Rat (Rattus)
»Alternatives Sheep
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN351203
Quantity 100 µL
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide as a part of rat and mouse transient receptor potential cation channel subfamily M member 4 (TRPM4) conjugated to immunogenic carrier protein was used as the immunogen. The antigen used is located in AA 1100-1180 of rat TRPM4.
Specificity Appears to be specific for TRPM4.
Purity whole serum
Alternative Name TRPM4 (Melastatin-like 2)
Background Function: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root andvomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload.
Enzyme regulation: Gating is voltage-dependent and repressed by decavanadate. Calmodulin-binding confers the Ca(2+) sensitivity. ATP is able to restore Ca(2+) sensitivity after desensitization. Phosphatidylinositol 4,5-biphosphate (PIP2)-binding strongly enhances activity, by increasing the channel's Ca(2+) sensitivity and shifting its voltage dependence of activation towards negative potentials. Activity is also enhanced by 3,5-bis(trifluoromethyl)pyrazole derivative (BTP2).
Subunit: Homomultimer.
Subcellular location: Cell membrane, Multi-pass membrane protein. Also known as: Transient receptor potential cation channel subfamily M member 4, Long transient receptor potential channel 4, Calcium-activated non-selective cation channel 1, Melastatin-like 2, MLS2s.
UniProt Q9ESQ5
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Nilius, Prenen, Droogmans et al.: "Voltage dependence of the Ca2+-activated cation channel TRPM4." in: The Journal of biological chemistry, Vol. 278, Issue 33, pp. 30813-20, 2003 (PubMed).

Murakami, Xu, Miyoshi et al.: "Identification and characterization of the murine TRPM4 channel." in: Biochemical and biophysical research communications, Vol. 307, Issue 3, pp. 522-8, 2003 (PubMed).

Guinamard, Chatelier, Lenfant et al.: "Activation of the Ca(2+)-activated nonselective cation channel by diacylglycerol analogues in rat cardiomyocytes." in: Journal of cardiovascular electrophysiology, Vol. 15, Issue 3, pp. 342-8, 2004 (PubMed).

Gibbs, Weinstock, Metzker et al.: "Genome sequence of the Brown Norway rat yields insights into mammalian evolution." in: Nature, Vol. 428, Issue 6982, pp. 493-521, 2004 (PubMed).

Guinamard, Demion, Magaud et al.: "Functional expression of the TRPM4 cationic current in ventricular cardiomyocytes from spontaneously hypertensive rats." in: Hypertension, Vol. 48, Issue 4, pp. 587-94, 2006 (PubMed).

Alternatives for antigen "Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4)", type "Antibodies"
Hosts (40), (7), (2), (1)
Reactivities (36), (20), (18), (1), (1)
Applications (34), (17), (14), (10), (8), (3)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (6), (4), (3), (2), (2), (1)