Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4) antibody

Details for Product No. ABIN351203
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Synonyms trpm4, TRPM4, PFHB1B, TRPM4B, LTrpC-4, Mls2s, 1110030C19Rik, AW047689, LTRPC4
Rat (Rattus), Mouse (Murine)
(61), (28), (26), (1), (1)
(55), (14), (1), (1), (1)
(3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(52), (26), (13), (13), (11), (10), (3), (2), (1)
Pubmed 5 references available
Quantity 100 μL
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Catalog No. ABIN351203
454.67 $
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Immunogen A synthetic peptide from mouse transient receptor potential cation channel subfamily M member 4 (TRPM4) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Specific for TRPM4.
Purification Whole serum
Alternative Name TRPM4
Background Function: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root andvomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload.
Enzyme regulation: Gating is voltage-dependent and repressed by decavanadate. Calmodulin-binding confers the Ca(2+) sensitivity. ATP is able to restore Ca(2+) sensitivity after desensitization. Phosphatidylinositol 4,5-biphosphate (PIP2)-binding strongly enhances activity, by increasing the channel's Ca(2+) sensitivity and shifting its voltage dependence of activation towards negative potentials. Activity is also enhanced by 3,5-bis(trifluoromethyl)pyrazole derivative (BTP2).
Subunit: Homomultimer.
Subcellular location: Cell membrane, Multi-pass membrane protein. Also known as: Transient receptor potential cation channel subfamily M member 4, Long transient receptor potential channel 4, Calcium-activated non-selective cation channel 1, Melastatin-like 2, MLS2s.
Research Area Signaling, Metabolism
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Guinamard, Demion, Magaud et al.: "Functional expression of the TRPM4 cationic current in ventricular cardiomyocytes from spontaneously hypertensive rats." in: Hypertension, Vol. 48, Issue 4, pp. 587-94, 2006 (PubMed).

Gibbs, Weinstock, Metzker et al.: "Genome sequence of the Brown Norway rat yields insights into mammalian evolution. ..." in: Nature, Vol. 428, Issue 6982, pp. 493-521, 2004 (PubMed).

Guinamard, Chatelier, Lenfant et al.: "Activation of the Ca(2+)-activated nonselective cation channel by diacylglycerol analogues in rat cardiomyocytes." in: Journal of cardiovascular electrophysiology, Vol. 15, Issue 3, pp. 342-8, 2004 (PubMed).

Murakami, Xu, Miyoshi et al.: "Identification and characterization of the murine TRPM4 channel." in: Biochemical and biophysical research communications, Vol. 307, Issue 3, pp. 522-8, 2003 (PubMed).

Nilius, Prenen, Droogmans et al.: "Voltage dependence of the Ca2+-activated cation channel TRPM4." in: The Journal of biological chemistry, Vol. 278, Issue 33, pp. 30813-20, 2003 (PubMed).

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