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Details for Product No. ABIN351208

Transient Receptor Potential Cation Channel, Subfamily M, Member 5 (TRPM5) (N-Term) antibody

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Antigen
Synonyms MTR1, LTRPC5, Mtr1, Ltrpc5, LTrpC-5, 9430099A16Rik
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN351208
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the 3d cytoplasmic of human TRPM5 (LTRPC5, MTR1, Long transient receptor potential channel 5) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Appears to be specific for TRPM5.
Purity whole serum
Alternative Name TRPM5 (LTRPC5)
Background Function: Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.
Subcellular location: Cell membrane, Multi-pass membrane protein.
Tissue specificity: Strongly expressed in fetal brain, liver and kidney, and in adult prostate, testis, ovary, colon and peripheral blood leukocytes. Also expressed in a large proportion of Wilms' tumors and rhabdomyosarcomas. In monochromosomal cell lines shows exclusive paternal expression. Also known as: LTRPC5, MLSN1- and TRP-related gene 1 protein, TRPM5, LTRPC5, MTR1, Transient receptor potential cation channel subfamily M member 5.
UniProt Q9NZQ8
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Prawitt, Enklaar, Klemm et al.: "Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression." in: Human molecular genetics, Vol. 9, Issue 2, pp. 203-16, 2000 (PubMed).

Prawitt, Monteilh-Zoller, Brixel et al.: "TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 25, pp. 15166-71, 2003 (PubMed).

Taylor, Noguchi, Totoki et al.: "Human chromosome 11 DNA sequence and analysis including novel gene identification." in: Nature, Vol. 440, Issue 7083, pp. 497-500, 2006 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Alternatives for antigen "Transient Receptor Potential Cation Channel, Subfamily M, Member 5 (TRPM5)", type "Antibodies"
Hosts (27), (3)
Reactivities (22), (18), (18), (12), (3), (2)
Applications (21), (10), (9), (9), (7), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (3), (1), (1), (1)
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