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Transient Receptor Potential Cation Channel, Subfamily M, Member 6 (TRPM6) (AA 1970-2020) antibody

Details for Product No. ABIN351209, Supplier: Log in to see
Antigen
  • TRPM6
  • CHAK2
  • HMGX
  • HOMG
  • HOMG1
  • HSH
  • TRPM6/CHAK2
Epitope
AA 1970-2020
14
10
3
2
1
1
1
1
1
1
1
Reactivity
Rat (Rattus)
36
20
17
Host
Rabbit
40
2
1
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
26
17
12
11
4
1
Supplier
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Immunogen A synthetic peptide from aa region 1970-2020 of rat TRPM6 conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for TRPM6.
Purification Whole serum
Alternative Name TRPM6 (TRPM6 Antibody Abstract)
Background Function: Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region.
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Subunit: Forms heterodimers with TRPM7. TRPM6 requires the presence of TRPM7 to be targeted to the cell membrane (in HEK 293 cells).
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Highly expressed in kidney and colon. Isoform TRPM6a and isoform TRPM6b, are coexpressed with TRPM7 in kidney, and testis, and are also found in several cell lines of lung origin. Isoform TRPM6c is detected only in testis and in H510 small cell lung carcinoma cells. Also known as: Transient receptor potential cation channel subfamily M member 6, channel kinase 2, melastatin-related TRP cation channel 6, CHAK2, HSH, HMGX, HOMG, HOMG1.
NCBI Accession XP_001078158
Research Area Signaling, Metabolism
Pathways
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Humphray, Oliver, Hunt et al.: "DNA sequence and analysis of human chromosome 9. ..." in: Nature, Vol. 429, Issue 6990, pp. 369-74, 2004 (PubMed).

Lee, Chen, Sun et al.: "Expression and characterization of human transient receptor potential melastatin 3 (hTRPM3)." in: The Journal of biological chemistry, Vol. 278, Issue 23, pp. 20890-7, 2003 (PubMed).

Grimm, Kraft, Sauerbruch et al.: "Molecular and functional characterization of the melastatin-related cation channel TRPM3." in: The Journal of biological chemistry, Vol. 278, Issue 24, pp. 21493-501, 2003 (PubMed).

Nagase, Kikuno, Nakayama et al.: "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 7, Issue 4, pp. 273-81, 2000 (PubMed).

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