Transient Receptor Potential Cation Channel, Subfamily M, Member 7 (TRPM7) (4th Cytoplasmic Loop) antibody

Details for Product No. ABIN351221
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Antigen
Synonyms ALSPDC, CHAK, CHAK1, LTRPC7, TRP-PLIK, Ltpr7, Ltrpc7, LTrpC-7, TRPPLIK, 2310022G15Rik, 4833414K03Rik, 5033407O22Rik, Chak, Trp-plik, cb495, TRPM7, chak, chak1, ltrpc7, trp-plik
Epitope
4th Cytoplasmic Loop
(17), (7), (5), (4), (2), (2), (2), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Human
(51), (38), (33), (20), (19), (17), (17), (2), (2)
Host
Rabbit
(49), (10), (9), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(45), (22), (21), (19), (14), (10), (10), (7), (2), (2), (2), (1)
Pubmed 5 references available
Catalog no. ABIN351221
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the 4th cytoplasmic loop of rat TRPM7 (LTrpC7, Channel-kinase 1, TRP-PLIK, Chak) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for TPC1.
Purification whole serum
Alternative Name TRPM7 (LTrpC7, Channel-kinase 1,TRP-PLIK, Chak)
Background Function: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Cofactor: Binds 1 zinc ion per subunit.
Subunit: Forms heterodimers with TRPM6. Homodimer.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Found to be expressed in brain and skeletal muscle, with stronger signals in kidney, heart, liver, and spleen (at protein level). Also known as: Long transient receptor potential channel 7, LTrpC7, Channel-kinase 1, Transient receptor potential-phospholipase C-interacting kinase, TRP-PLIK, Chak.
UniProt Q9ULQ1
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other application.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Runnels, Yue, Clapham: "TRP-PLIK, a bifunctional protein with kinase and ion channel activities." in: Science (New York, N.Y.), Vol. 291, Issue 5506, pp. 1043-7, 2001 (PubMed).

Nadler, Hermosura, Inabe et al.: "LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability." in: Nature, Vol. 411, Issue 6837, pp. 590-5, 2001 (PubMed).

Yamaguchi, Matsushita, Nairn et al.: "Crystal structure of the atypical protein kinase domain of a TRP channel with phosphotransferase activity." in: Molecular cell, Vol. 7, Issue 5, pp. 1047-57, 2001 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome...." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Villén, Beausoleil, Gerber et al.: "Large-scale phosphorylation analysis of mouse liver." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 5, pp. 1488-93, 2007 (PubMed).

Hosts (49), (10), (9), (1)
Reactivities (51), (38), (33), (20), (19), (17), (17), (2), (2)
Applications (45), (22), (21), (19), (14), (10), (10), (7), (2), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (17), (7), (5), (4), (2), (2), (2), (1), (1)
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