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TRPM7 antibody (Transient Receptor Potential Cation Channel, Subfamily M, Member 7) (4th Cytoplasmic Loop)

Details for Product anti-TRPM7 Antibody No. ABIN351222, Supplier: Log in to see
Antigen
  • cb495
  • TRPM7
  • chak
  • chak1
  • ltrpc7
  • trp-plik
  • ALSPDC
  • CHAK
  • CHAK1
  • LTRPC7
  • TRP-PLIK
  • 2310022G15Rik
  • 4833414K03Rik
  • 5033407O22Rik
  • LTrpC-7
  • Ltpr7
  • Ltrpc7
  • TRPPLIK
  • Chak
  • Trp-plik
Epitope
4th Cytoplasmic Loop
78
38
24
13
7
3
3
2
1
1
1
1
1
1
1
Reactivity
Rat (Rattus)
111
80
56
4
4
2
2
1
1
1
1
1
Host
Rabbit
83
44
17
3
Clonality
Polyclonal
Conjugate
This TRPM7 antibody is un-conjugated
8
8
7
7
7
7
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
109
77
56
40
35
26
22
11
5
2
2
1
Supplier
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Immunogen A synthetic peptide from the 4th cytoplasmic loop of rat TRPM7 conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for TRPM7.
Purification Whole serum
Alternative Name TRPM7 (TRPM7 Antibody Abstract)
Background Function: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Cofactor: Binds 1 zinc ion per subunit.
Subunit: Forms heterodimers with TRPM6. Homodimer.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Found to be expressed in brain and skeletal muscle, with stronger signals in kidney, heart, liver, and spleen (at protein level). Also known as: Long transient receptor potential channel 7, LTrpC7, Channel-kinase 1, Transient receptor potential-phospholipase C-interacting kinase, TRP-PLIK, Chak.
Research Area Neurology
Pathways
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Villén, Beausoleil, Gerber et al.: "Large-scale phosphorylation analysis of mouse liver." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 5, pp. 1488-93, 2007 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome. ..." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Yamaguchi, Matsushita, Nairn et al.: "Crystal structure of the atypical protein kinase domain of a TRP channel with phosphotransferase activity." in: Molecular cell, Vol. 7, Issue 5, pp. 1047-57, 2001 (PubMed).

Nadler, Hermosura, Inabe et al.: "LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability." in: Nature, Vol. 411, Issue 6837, pp. 590-5, 2001 (PubMed).

Runnels, Yue, Clapham: "TRP-PLIK, a bifunctional protein with kinase and ion channel activities." in: Science (New York, N.Y.), Vol. 291, Issue 5506, pp. 1043-7, 2001 (PubMed).

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