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Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) (4th Cytoplasmic Loop) antibody

Details for Product No. ABIN351223
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Antigen
Synonyms LTRPC6, TRPP8, CMR1, LTrpC-6, Trp-p8, TRPM8, trpp8, ltrpc6, trpm8b
Epitope
4th Cytoplasmic Loop
(10), (6), (5), (5), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Mouse (Murine)
(73), (29), (27), (13), (1), (1), (1), (1)
Host
Goat
(82), (2), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(59), (28), (25), (23), (10), (9), (4), (2), (2), (1), (1), (1), (1)
Pubmed 6 references available
Quantity 100 µL
Options
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Availability Will be delivered in 7 to 8 Business Days
Catalog No. ABIN351223
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide from the 4th cytoplasmic loop of rat TRPM8, conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for VMAT1.
Purification whole serum
Alternative Name TRPM8
Background Function: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
Subcellular location: Membrane, Multi-pass membrane protein (Probable).
Tissue specificity: Expressed in dorsal root and trigeminal ganglia. Specifically expressed in a subset of sensory neurons, including cold-sensitive neurons in trigeminal neurons. SIMILARITY: Belongs to the transient receptor family, LTrpC subfamily. Also known as: Transient receptor potential cation channel subfamily M member 8, Cold menthol receptor 1, Trpm8, Trpm8 transient receptor potential cation channel, subfamily M, member 8, CMR1.
UniProt Q8R090
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
Supplier Images
anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) (4th Cytoplasmic Loop) antibody IF on rat olfactory bulb using Rabbit antibody to rat TRPM8: whole serum at 1 : 500 dilution and DAPI counterstained.
anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) (4th Cytoplasmic Loop) antibody (2) IF on rat olfactory bulb using Rabbit antibody to rat TRPM8: whole serum at 1 : 500 dilution and DAPI counterstained appearing in blue.
anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) (4th Cytoplasmic Loop) antibody (3) IF on rat olfactory bulb using Rabbit antibody to rat TRPM8: whole serum at 1 : 500 dilution and DAPI counterstained appearing in blue.
General McKemy, Neuhausser, Julius: "Identification of a cold receptor reveals a general role for TRP channels in thermosensation." in: Nature, Vol. 416, Issue 6876, pp. 52-8, 2002 (PubMed).

Nealen, Gold, Thut et al.: "TRPM8 mRNA is expressed in a subset of cold-responsive trigeminal neurons from rat." in: Journal of neurophysiology, Vol. 90, Issue 1, pp. 515-20, 2003 (PubMed).

Abe, Hosokawa, Okazawa et al.: "TRPM8 protein localization in trigeminal ganglion and taste papillae." in: Brain research. Molecular brain research, Vol. 136, Issue 1-2, pp. 91-8, 2005 (PubMed).

Frederick, Buck, Matson et al.: "Increased TRPA1, TRPM8, and TRPV2 expression in dorsal root ganglia by nerve injury." in: Biochemical and biophysical research communications, Vol. 358, Issue 4, pp. 1058-64, 2007 (PubMed).

Brauchi, Orta, Mascayano et al.: "Dissection of the components for PIP2 activation and thermosensation in TRP channels." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 24, pp. 10246-51, 2007 (PubMed).

Monreal: "Restoration of elbow flexion by transfer of the phrenic nerve to musculocutaneous nerve after brachial plexus injuries." in: Hand (New York, N.Y.), Vol. 2, Issue 4, pp. 206-11, 2008 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN351223
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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