Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) (Extracellular Loop) antibody

Details for Product No. ABIN351226
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Antigen
Synonyms LTRPC6, TRPP8, CMR1, LTrpC-6, Trp-p8, TRPM8, trpp8, ltrpc6, trpm8b
Epitope
Extracellular Loop
(10), (6), (5), (5), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(74), (30), (27), (13), (1), (1), (1), (1)
Host
Rabbit
(82), (3), (2), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(61), (30), (25), (25), (10), (4), (4), (3), (2), (1), (1), (1), (1)
Pubmed 3 references available
Catalog no. ABIN351226
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
Options
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide from the 3d extracellular loop of human TRPM8 (LTRPC6, TRPP8, LTrpC6) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for KCNK5.
Purification whole serum
Alternative Name TRPM8 (LTRPC6,TRPP8, LtrpC6)
Background Function: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in prostate. Also expressed in most in prostate tumors. Also expressed in non-prostatic primary tumors such as colon, lung, breast and skin tumors.
Miscellaneous: The sensation of coolness triggered by eucalyptol or menthol may be explained by the fact that menthol and cool temperatures sensations are detected by this protein. Its expression in most prostate tumors as well as the presence of an immunogenic epitope suggest that it may be suitable for the design of peptide vaccination strategies for prostate cancers. Also known as: Transient receptor potential cation channel subfamily M member 8, transient receptor potential-p8, Trp-p8, long transient receptor potential channel 6, LTrpC6, TRPP8, LTRPC6, MGC2849.
UniProt O95279
Research Area Signaling, Metabolism
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Tsavaler, Shapero, Morkowski et al.: "Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins." in: Cancer research, Vol. 61, Issue 9, pp. 3760-9, 2001 (PubMed).

Kiessling, Füssel, Schmitz et al.: "Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein trp-p8." in: The Prostate, Vol. 56, Issue 4, pp. 270-9, 2003 (PubMed).

Voets, Droogmans, Wissenbach et al.: "The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels." in: Nature, Vol. 430, Issue 7001, pp. 748-54, 2004 (PubMed).

Hosts (82), (3), (2), (2)
Reactivities (74), (30), (27), (13), (1), (1), (1), (1)
Applications (61), (30), (25), (25), (10), (4), (4), (3), (2), (1), (1), (1), (1)
Conjugates (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (6), (5), (5), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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