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Details for Product No. ABIN351262

Transient Receptor Potential Cation Channel, Subfamily V, Member 2 (TRPV2) (1st Cytoplasmic Loop) antibody

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Synonyms VRL, VRL-1, VRL1, GRC, Vrl1, OTRPC2, TRPV2
»Alternatives 1st Cytoplasmic Loop
»Alternatives Human
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 6 references available
Catalog no. ABIN351262
Quantity 100 µL
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the 1t cytoplasmic loop of human TRPV2 (VRL, VRL1, VRL-1, OTRPC2) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Appears to be specific for TRPV3.
Purity whole serum
Alternative Name TRPV2 (VRL, VRL1, VRL-1, OTRPC2)
Background This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat.
Function: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius, is not activated by vanilloids and acidic pH.
Subunit: Homotetramer. Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with RGA.
Subcellular location: Cell membrane, Multi-pass membrane protein. Cytoplasm. Melanosome. Note: Translocates from the cytoplasm to the plasma membrane upon ligand stimulation. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Also known as: Transient receptor potential cation channel subfamily V member 2, TrpV2, osm-9-like TRP channel 2, OTRPC2, vanilloid receptor-like protein, VRL, VRL1, VRL-1, OTRPC2, MGC12549.
UniProt Q9Y5S1
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 3000 is recommended. The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Caterina, Rosen, Tominaga et al.: "A capsaicin-receptor homologue with a high threshold for noxious heat." in: Nature, Vol. 398, Issue 6726, pp. 436-41, 1999 (PubMed).

Smith, Gunthorpe, Kelsell et al.: "TRPV3 is a temperature-sensitive vanilloid receptor-like protein." in: Nature, Vol. 418, Issue 6894, pp. 186-90, 2002 (PubMed).

Voets, Prenen, Vriens et al.: "Molecular determinants of permeation through the cation channel TRPV4." in: The Journal of biological chemistry, Vol. 277, Issue 37, pp. 33704-10, 2002 (PubMed).

Clapham, Julius, Montell et al.: "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels." in: Pharmacological reviews, Vol. 57, Issue 4, pp. 427-50, 2005 (PubMed).

Penna, Juvin, Chemin et al.: "PI3-kinase promotes TRPV2 activity independently of channel translocation to the plasma membrane." in: Cell calcium, Vol. 39, Issue 6, pp. 495-507, 2006 (PubMed).

Saunders, Kunde, Crawford et al.: "Expression of transient receptor potential vanilloid 1 (TRPV1) and 2 (TRPV2) in human peripheral blood." in: Molecular immunology, Vol. 44, Issue 6, pp. 1429-35, 2006 (PubMed).

Alternatives for antigen "Transient Receptor Potential Cation Channel, Subfamily V, Member 2 (TRPV2)", type "Antibodies"
Hosts (51), (7), (3)
Reactivities (29), (29), (24)
Applications (32), (22), (15), (11), (10), (9), (4), (4), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (5), (4), (3), (2), (2), (1), (1), (1), (1), (1)