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TRPV2 antibody (Transient Receptor Potential Cation Channel, Subfamily V, Member 2) (3rd Extracellular Loop)

Details for Product anti-TRPV2 Antibody No. ABIN351263, Supplier: Log in to see
Antigen
  • GRC
  • OTRPC2
  • TRPV2
  • VRL
  • VRL-1
  • VRL1
  • Vrl1
Epitope
3rd Extracellular Loop
30
27
15
6
3
3
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human
71
23
14
2
2
2
1
1
1
1
1
Host
Rabbit
69
28
2
Clonality
Polyclonal
Conjugate
This TRPV2 antibody is un-conjugated
4
4
4
4
4
4
Application
Immunohistochemistry (IHC), Western Blotting (WB)
62
42
27
25
4
4
2
1
1
Supplier
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Immunogen A synthetic peptide from the 3d extracellular loop of human TRPV2 conjugated to blue carrier protein was used as the antigen.
Specificity Specific for TRPV2.
Purification Whole serum
Alternative Name TRPV2 (TRPV2 Antibody Abstract)
Background This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat.
Function: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius, is not activated by vanilloids and acidic pH.
Subcellular location: Cell membrane, Multi-pass membrane protein. Cytoplasm. Melanosome. Note: Translocates from the cytoplasm to the plasma membrane upon ligand stimulation. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Also known as: Transient receptor potential cation channel subfamily V member 2, TrpV2, osm-9-like TRP channel 2, OTRPC2, vanilloid receptor-like protein, VRL, VRL1, VRL-1, OTRPC2, MGC12549.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Saunders, Kunde, Crawford, Geraghty: "Expression of transient receptor potential vanilloid 1 (TRPV1) and 2 (TRPV2) in human peripheral blood." in: Molecular immunology, Vol. 44, Issue 6, pp. 1429-35, 2006 (PubMed).

Penna, Juvin, Chemin, Compan, Monet, Rassendren: "PI3-kinase promotes TRPV2 activity independently of channel translocation to the plasma membrane." in: Cell calcium, Vol. 39, Issue 6, pp. 495-507, 2006 (PubMed).

Clapham, Julius, Montell, Schultz: "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels." in: Pharmacological reviews, Vol. 57, Issue 4, pp. 427-50, 2005 (PubMed).

Smith, Gunthorpe, Kelsell, Hayes, Reilly, Facer, Wright, Jerman, Walhin, Ooi, Egerton, Charles, Smart, Randall, Anand, Davis: "TRPV3 is a temperature-sensitive vanilloid receptor-like protein." in: Nature, Vol. 418, Issue 6894, pp. 186-90, 2002 (PubMed).

Voets, Prenen, Vriens, Watanabe, Janssens, Wissenbach, Boedding, Droogmans, Nilius: "Molecular determinants of permeation through the cation channel TRPV4." in: The Journal of biological chemistry, Vol. 277, Issue 37, pp. 33704-10, 2002 (PubMed).

Caterina, Rosen, Tominaga, Brake, Julius: "A capsaicin-receptor homologue with a high threshold for noxious heat." in: Nature, Vol. 398, Issue 6726, pp. 436-41, 1999 (PubMed).