Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN351264

Transient Receptor Potential Cation Channel, Subfamily V, Member 2 (TRPV2) (4th Cytoplasmic Loop) antibody

Request
Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms VRL, VRL-1, VRL1, GRC, Vrl1, OTRPC2, TRPV2
Epitope
»Alternatives 4th Cytoplasmic Loop
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 6 references available
Catalog no. ABIN351264
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the 4th cytoplasmic loop of human TRPV2 (VRL, VRL1, VRL-1, OTRPC2) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Appears to be specific for TRPV2.
Purity whole serum
Alternative Name TRPV2 (VRL, VRL1, VRL-1, OTRPC2)
Background This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat.
Function: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius, is not activated by vanilloids and acidic pH.
Subunit: Homotetramer. Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with RGA.
Subcellular location: Cell membrane, Multi-pass membrane protein. Cytoplasm. Melanosome. Note: Translocates from the cytoplasm to the plasma membrane upon ligand stimulation. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Also known as: Transient receptor potential cation channel subfamily V member 2, TrpV2, osm-9-like TRP channel 2, OTRPC2, vanilloid receptor-like protein, VRL, VRL1, VRL-1, OTRPC2, MGC12549.
UniProt Q9Y5S1
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Caterina, Rosen, Tominaga et al.: "A capsaicin-receptor homologue with a high threshold for noxious heat." in: Nature, Vol. 398, Issue 6726, pp. 436-41, 1999 (PubMed).

Smith, Gunthorpe, Kelsell et al.: "TRPV3 is a temperature-sensitive vanilloid receptor-like protein." in: Nature, Vol. 418, Issue 6894, pp. 186-90, 2002 (PubMed).

Voets, Prenen, Vriens et al.: "Molecular determinants of permeation through the cation channel TRPV4." in: The Journal of biological chemistry, Vol. 277, Issue 37, pp. 33704-10, 2002 (PubMed).

Clapham, Julius, Montell et al.: "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels." in: Pharmacological reviews, Vol. 57, Issue 4, pp. 427-50, 2005 (PubMed).

Penna, Juvin, Chemin et al.: "PI3-kinase promotes TRPV2 activity independently of channel translocation to the plasma membrane." in: Cell calcium, Vol. 39, Issue 6, pp. 495-507, 2006 (PubMed).

Saunders, Kunde, Crawford et al.: "Expression of transient receptor potential vanilloid 1 (TRPV1) and 2 (TRPV2) in human peripheral blood." in: Molecular immunology, Vol. 44, Issue 6, pp. 1429-35, 2006 (PubMed).

Alternatives for antigen "Transient Receptor Potential Cation Channel, Subfamily V, Member 2 (TRPV2)", type "Antibodies"
Hosts (51), (7), (3)
Reactivities (29), (29), (24)
Applications (32), (22), (15), (11), (10), (9), (4), (4), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (5), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Beacon