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Transient Receptor Potential Cation Channel, Subfamily V, Member 2 (TRPV2) (3rd Extracellular Loop) antibody

Details for Product No. ABIN351266, Supplier: Log in to see
Antigen
  • TRPV2
  • VRL
  • VRL-1
  • VRL1
  • Vrl1
  • GRC
  • OTRPC2
Epitope
3rd Extracellular Loop
29
25
15
6
3
3
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Rat (Rattus)
67
22
14
1
1
1
1
1
1
1
1
Host
Rabbit
66
26
2
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
4
4
4
4
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
58
40
23
22
4
3
1
1
1
1
Supplier
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Immunogen A synthetic peptide from the 3d extracellular loop of rat TRPV2 (VRL-1) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Specific for TRPV2.
Purification Whole serum
Alternative Name TRPV2 (TRPV2 Antibody Abstract)
Background Function: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius, is not activated by vanilloids and acidic pH.
Subunit: Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with RGA.
Subcellular location: Cell membrane, Multi-pass membrane protein. Cytoplasm. Melanosome.
Tissue specificity: Ubiquitously expressed. Expressed in dorsal root ganglia, trigeminal ganglia, spinal chord (Lissauer's tract, dorsal horn and dorsal columns) (at protein level). PTM: N-glycosylated. PTM: Phosphorylated by PKA. SIMILARITY: Belongs to the transient receptor family, TrpV subfamily. SIMILARITY: Contains 3 ANK repeats. Also known as: Transient receptor potential cation channel subfamily V member 2, TrpV2, osm-9-like TRP channel 2, OTRPC2, Vanilloid receptor-like protein 1, VRL-1, Stretch-activated channel 2B, Sac2b, Vrl1, MGC105451.
Pathways
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Frederick, Buck, Matson et al.: "Increased TRPA1, TRPM8, and TRPV2 expression in dorsal root ganglia by nerve injury." in: Biochemical and biophysical research communications, Vol. 358, Issue 4, pp. 1058-64, 2007 (PubMed).

Stokes, Shimoda, Koblan-Huberson et al.: "A TRPV2-PKA signaling module for transduction of physical stimuli in mast cells." in: The Journal of experimental medicine, Vol. 200, Issue 2, pp. 137-47, 2004 (PubMed).

Ichikawa, Sugimoto: "The co-expression of VR1 and VRL-1 in the rat vagal sensory ganglia." in: Brain research, Vol. 980, Issue 2, pp. 293-6, 2003 (PubMed).

Zahner, Li, Chen et al.: "Cardiac vanilloid receptor 1-expressing afferent nerves and their role in the cardiogenic sympathetic reflex in rats." in: The Journal of physiology, Vol. 551, Issue Pt 2, pp. 515-23, 2003 (PubMed).

Jung, Lee, Hwang et al.: "Agonist recognition sites in the cytosolic tails of vanilloid receptor 1." in: The Journal of biological chemistry, Vol. 277, Issue 46, pp. 44448-54, 2002 (PubMed).

Caterina, Rosen, Tominaga et al.: "A capsaicin-receptor homologue with a high threshold for noxious heat." in: Nature, Vol. 398, Issue 6726, pp. 436-41, 1999 (PubMed).