Transient Receptor Potential Cation Channel, Subfamily V, Member 3 (TRPV3) (1t cytoplasmic domain) antibody

Antigen: Transient Receptor Potential Cation Channel, Subfamily V, Member 3 (TRPV3)

Synonyms: VRL3, Nh, AI644701, MGC124324, MGC124325, 1110036I10Rik, TRPV3, MGC159979

Epitope: 1t cytoplasmic domain

Clonality: Polyclonal

Host: Rabbit

Reactivity: Mouse (Murine)

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN351270

Additional Information

Alternative name: TRPV3 (1t cytoplasmic domain)

Swiss-Prot: Q8K424

Immunogen: A synthetic peptide from mouse TRPV3 conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. SUBUNIT: May form a heteromeric channel with TRPV1. Interacts with TRPV1. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in keratinocytes and hair follicles. Also known as: Trpv3 transient receptor potential cation channel, subfamily V, member 3, Nh, VRL3, AI644701, MGC124324, MGC124325, 1110036I10Rik.

Specificity: Appears to be specific for TRPV3.

Application Details

Application Notes: IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Research Area: Neurology

Restrictions: For Research Use only

Publications

Publications: Haraguchi, Hino, Tanaka et al.: "Naturally occurring dermatitis associated with Staphylococcus aureus in DS-Nh mice." in: Experimental animals / Japanese Association for Laboratory Animal Science, Vol. 46, Issue 3, pp. 225-9, 1997 (PubMed).

Peier, Reeve, Andersson et al.: "A heat-sensitive TRP channel expressed in keratinocytes." in: Science (New York, N.Y.), Vol. 296, Issue 5575, pp. 2046-9, 2002 (PubMed).

Yoshioka, Hikita, Asakawa et al.: "Spontaneous scratching behaviour in DS-Nh mice as a possible model for pruritus in atopic dermatitis." in: Immunology, Vol. 118, Issue 3, pp. 293-301, 2006 (PubMed).

Asakawa, Yoshioka, Matsutani et al.: "Association of a mutation in TRPV3 with defective hair growth in rodents." in: The Journal of investigative dermatology, Vol. 126, Issue 12, pp. 2664-72, 2006 (PubMed).