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Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4) (1st Cytoplasmic Loop) antibody

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Synonyms wu:fp52e02, CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VRL2, VROAC, 0610033B08Rik, Trp12, VR-OAC, VRL-2, Otrpc4, Vroac
1st Cytoplasmic Loop
(25), (18), (10), (6), (5), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
(84), (39), (36), (5), (4), (4), (3), (2)
(91), (5), (1)
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(71), (27), (26), (11), (11), (2)
Pubmed 5 references available
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Quantity 100 μL
Shipping to United States ( )
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the 1t cytoplasmic loop of human TRPV4 (VRL-2, VRL2) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for TRPV4.
Purification Whole serum
Alternative Name TRPV4 (TRPV4 Antibody Abstract)
Background This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure.
Function: Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism.
Subcellular location: Membrane, Multi-pass membrane protein. Note: Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum. Also known as: Transient receptor potential cation channel subfamily V member 4, TrpV4, osm-9-like TRP channel 4, OTRPC4, vanilloid receptor-like channel 2, vanilloid receptor-like protein 2, VRL-2, vanilloid receptor-related osmotically-activated channel, VR-OAC, transient receptor potential protein 12, TRP12, VRL2, TRP12, VROAC.
Research Area Neurology
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Arniges, Fernuandez-Fernuandez, Albrecht et al.: "Human TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and trafficking." in: The Journal of biological chemistry, Vol. 281, Issue 3, pp. 1580-6, 2006 (PubMed).

Strotmann, Schultz, Plant: "Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site." in: The Journal of biological chemistry, Vol. 278, Issue 29, pp. 26541-9, 2003 (PubMed).

Suzuki, Mizuno, Kodaira et al.: "Impaired pressure sensation in mice lacking TRPV4." in: The Journal of biological chemistry, Vol. 278, Issue 25, pp. 22664-8, 2003 (PubMed).

Liedtke, Choe, Martí-Renom et al.: "Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor." in: Cell, Vol. 103, Issue 3, pp. 525-35, 2000 (PubMed).

Strotmann, Harteneck, Nunnenmacher et al.: "OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity." in: Nature cell biology, Vol. 2, Issue 10, pp. 695-702, 2000 (PubMed).

Catalog No. ABIN351287
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