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Transient Receptor Potential Cation Channel, Subfamily V, Member 5 (TRPV5) antibody

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Synonyms TRPV5, CAT2, D630033B11, ECAC1, OTRPC3, CaT2, Ecac1, ECAC
Mouse (Murine)
(68), (28), (23), (5), (5), (4), (2), (1)
(50), (16), (7), (6)
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(64), (39), (15), (11), (10), (8), (3), (2), (2)
Pubmed 8 references available
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Quantity 100 μL
Shipping to United States ( )
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from mouse TRPV5 conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for TRPV5.
Purification Whole serum
Alternative Name TRPV5 (TRPV5 Antibody Abstract)
Background Function: Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
Subcellular location: Apical cell membrane, Multi-pass membrane protein. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells. Also known as: Transient receptor potential cation channel subfamily V member 5, TrpV5, osm-9-like TRP channel 3, OTRPC3, Epithelial calcium channel 1, ECaC1, Calcium transporter 2, CaT2, Ecac,CAT2, ECAC1, MGC129346, MGC129347, D630033B11.
Research Area Signaling, Metabolism
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Topala, Bindels, Hoenderop: "Regulation of the epithelial calcium channel TRPV5 by extracellular factors." in: Current opinion in nephrology and hypertension, Vol. 16, Issue 4, pp. 319-24, 2007 (PubMed).

Nakaya, Harbidge, Wangemann et al.: "Lack of pendrin HCO3- transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channels." in: American journal of physiology. Renal physiology, Vol. 292, Issue 5, pp. F1314-21, 2007 (PubMed).

van Abel, Huybers, Hoenderop et al.: "Age-dependent alterations in Ca2+ homeostasis: role of TRPV5 and TRPV6." in: American journal of physiology. Renal physiology, Vol. 291, Issue 6, pp. F1177-83, 2006 (PubMed).

van de Graaf, van der Kemp, van den Berg et al.: "Identification of BSPRY as a novel auxiliary protein inhibiting TRPV5 activity." in: Journal of the American Society of Nephrology : JASN, Vol. 17, Issue 1, pp. 26-30, 2005 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome. ..." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Lambers, Weidema, Nilius et al.: "Regulation of the mouse epithelial Ca2(+) channel TRPV6 by the Ca(2+)-sensor calmodulin." in: The Journal of biological chemistry, Vol. 279, Issue 28, pp. 28855-61, 2004 (PubMed).

van de Graaf, Hoenderop, Gkika et al.: "Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex." in: The EMBO journal, Vol. 22, Issue 7, pp. 1478-87, 2003 (PubMed).

Nilius, Prenen, Hoenderop et al.: "Fast and slow inactivation kinetics of the Ca2+ channels ECaC1 and ECaC2 (TRPV5 and TRPV6). Role of the intracellular loop located between transmembrane segments 2 and 3." in: The Journal of biological chemistry, Vol. 277, Issue 34, pp. 30852-8, 2002 (PubMed).

Catalog No. ABIN351292
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