Transient Receptor Potential Cation Channel, Subfamily V, Member 6 (TRPV6) (1st extracellular loop) antibody

Antigen: Transient Receptor Potential Cation Channel, Subfamily V, Member 6 (TRPV6)

Synonyms: CAT1, CATL, ZFAB, ECAC2, ABP/ZF, LP6728, HSA277909, CAT, Cac, CaT1, Ecac2, Otrpc3, TRPV6, trpv6, CaT, ECaC, ecac, MGC162545

Epitope: 1st extracellular loop

Clonality: Polyclonal

Host: Sheep

Reactivity: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN351305

Additional Information

Alternative name: TRPV6 (1t extracellular loop)

Swiss-Prot: Q4U456

Immunogen: A synthetic peptide from the 1t extracellular loop of rabbit TRPV6 conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. SUBUNIT: Homotetramer and probably heterotetramer with TRPV5. Interacts with TRPV5, heterotetramer. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in duodenum, proximal jejunum, cecum, and colon. SIMILARITY: Belongs to the transient receptor family, TrpV subfamily. SIMILARITY: Contains 5 ANK repeats. Also known as: Transient receptor potential cation channel subfamily V member 6, TrpV6, Epithelial calcium channel 2, ECaC2, Calcium transport protein 1, CaT1, Trpv6 transient receptor potential cation channel, subfamily V, member 6, CaT1, Ecac2, Otrpc3.

Specificity: Appears to be specific for TRPV6.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 4000 is recommended. The optimal dilution should be determined by the end user.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Peng, Chen, Berger et al.: "Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption." in: The Journal of biological chemistry, Vol. 274, Issue 32, pp. 22739-46, 1999 (PubMed).

Yue, Peng, Hediger et al.: "CaT1 manifests the pore properties of the calcium-release-activated calcium channel." in: Nature, Vol. 410, Issue 6829, pp. 705-9, 2001 (PubMed).

Boedding, Wissenbach, Flockerzi: "The recombinant human TRPV6 channel functions as Ca2+ sensor in human embryonic kidney and rat basophilic leukemia cells." in: The Journal of biological chemistry, Vol. 277, Issue 39, pp. 36656-64, 2002 (PubMed).