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Tumor Susceptibility Gene 101 (TSG101) (AA 280-330) antibody

Details for Product No. ABIN351312
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Antigen
Synonyms CG9712, DmTSG101, Dmel\\CG9712, ESCRT-I, Tsg101, burs, dTSg101, dTsg101, dVps23, ept, tsg101, vps23, TSG101, MGC76193, TSG10, VPS23, AI255943, CC2, Rw, zgc:86926
Epitope
AA 280-330
(13), (9), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Human
(68), (33), (26), (15), (15), (2), (1), (1), (1), (1)
Host
Rabbit
(63), (12)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(63), (35), (21), (14), (14), (10), (8), (4), (2), (1), (1), (1)
Pubmed 5 references available
Quantity 500 µg
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Catalog No. ABIN351312
454.67 $
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Immunogen A synthetic peptide from aa region 280-330 of rat TSG101 conjugated to an immunogenic carrier protein was used as the antigen.
Isotype IgG
Specificity Specific for TSG101.
Alternative Name TSG101
Background Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. Acts as a negative growth regulator.
Subunit: Component of ESCRT-I, endosomal sorting complex required for transport I, which consists of VPS28, VPS37, and TSG101. Interacts with VPS37A, VPS37B and VPS37C. Interacts with ubiquitin, stathmin, GMCL, DMAP1, HGS and AATF. Binds GGA1 and GGA3. Interacts with PDCD6IP/AIP1.
Subcellular location: Cytoplasm. Membrane, Peripheral membrane protein. Nucleus. Note: Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Depending on the stage of the cell cycle, detected in the nucleus. Also known as: Tumor susceptibility gene 101 protein.
Research Area Cancer, Cell Cycle
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Li, Li, Francke et al.: "The TSG101 tumor susceptibility gene is located in chromosome 11 band p15 and is mutated in human breast cancer." in: Cell, Vol. 88, Issue 1, pp. 143-54, 1997 (PubMed).

Gayther, Barski, Batley et al.: "Aberrant splicing of the TSG101 and FHIT genes occurs frequently in multiple malignancies and in normal tissues and mimics alterations previously described in tumours." in: Oncogene, Vol. 15, Issue 17, pp. 2119-26, 1997 (PubMed).

Rountree, Bachman, Baylin: "DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci." in: Nature genetics, Vol. 25, Issue 3, pp. 269-77, 2000 (PubMed).

Lu, Hope, Brasch et al.: "TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 13, pp. 7626-31, 2003 (PubMed).

Burgdorf, Leister, Scheidtmann: "TSG101 interacts with apoptosis-antagonizing transcription factor and enhances androgen receptor-mediated transcription by promoting its monoubiquitination." in: The Journal of biological chemistry, Vol. 279, Issue 17, pp. 17524-34, 2004 (PubMed).

Validation Images
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