Unc-51 Like Kinase 1 (C. Elegans) (ULK1) (AA 350-410) antibody

Details for Product No. ABIN351313
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Antigen
Synonyms ULK1, si:dkey-11o18.7, ulk1, ATG1, ATG1A, UNC51, Unc51.1, hATG1, AU041434, mKIAA0722
Epitope
AA 350-410
(30), (14), (12), (9), (9), (8), (8), (7), (7), (6), (6), (3), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(128), (32), (29), (24), (12), (12), (2), (1)
Host
Rabbit
(121), (4), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(12), (12), (12), (10), (10), (10), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(70), (68), (36), (20), (15), (7), (5), (3), (2), (2), (1), (1)
Pubmed 7 references available
Quantity 150 μL
Options
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Catalog No. ABIN351313
454.67 $
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Immunogen A synthetic peptide from aa region 350-410 of human ULK1 conjugated to an immunogenic carrier protein has been used as the antigen. The peptide is homologous in rat and mouse.
Specificity Specific for ULK1.
Purification Whole serum
Alternative Name ULK1
Background Function: Involved in axon growth. Plays an essential role in neurite extension of cerebellar granule cells.
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Subunit: Interacts with GABARAP and GABARAPL2. Also known as: Unc-51-like kinase 1, serine/threonine-protein kinase, ATG1.
Research Area Cardiovascular, Autophagy
Application Notes Use at a dilution of 1 : 200 to 1 : 2000.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Kuroyanagi, Yan, Seki et al.: "Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment." in: Genomics, Vol. 51, Issue 1, pp. 76-85, 1998 (PubMed).

Okazaki, Yan, Yuasa et al.: "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation." in: Brain research. Molecular brain research, Vol. 85, Issue 1-2, pp. 1-12, 2001 (PubMed).

Tomoda, Kim, Zhan et al.: "Role of Unc51.1 and its binding partners in CNS axon outgrowth." in: Genes & development, Vol. 18, Issue 5, pp. 541-58, 2004 (PubMed).

Young, Chan, Hu et al.: "Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes." in: Journal of cell science, Vol. 119, Issue Pt 18, pp. 3888-900, 2006 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Wissing, Jänsch, Nimtz et al.: "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 3, pp. 537-47, 2007 (PubMed).

Chan, Kir, Tooze: "siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy." in: The Journal of biological chemistry, Vol. 282, Issue 35, pp. 25464-74, 2007 (PubMed).

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