Vacuolar Protein Sorting 37 Homolog A (S. Cerevisiae) (VPS37A) (C-Term) antibody

Antigen: Vacuolar Protein Sorting 37 Homolog A (S. Cerevisiae) (VPS37A)

Synonyms: AW261445, D8Ertd531e, 2210018P21Rik, 4930592A21Rik, MGC116266, fb08f03, fj42c03, zgc:73244, zgc:77637, wu:fb08f03, wu:fj42c03, MGC137205, HCRP1, PQBP2, FLJ32642, FLJ42616, MGC115147

Epitope: C-Term

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN351327

Additional Information

Alternative name: Vacuolar protein sorting associated protein 37A (VPS37A) (c-terminal)

Swiss-Prot: Q8NEZ2

Immunogen: A synthetic peptide from the c-terminal of human Vacuolar protein sorting-associated protein 37A (VPS37A, Hepatocellular carcinoma-related protein 1) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse.

Format: Lyophilized

Description: FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. SUBCELLULAR LOCATION: Cytoplasm. Late endosome membrane; Peripheral membrane protein. Nucleus. Also known as: VPS37A, Hepatocellular carcinoma-related protein 1.

Specificity: Appears to be specific for VPS37A.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Xu, Liang, Wang et al.: "HCRP1, a novel gene that is downregulated in hepatocellular carcinoma, encodes a growth-inhibitory protein." in: Biochemical and biophysical research communications, Vol. 311, Issue 4, pp. 1057-66, 2003 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Stuchell, Garrus, Mueller et al.: "The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding." in: The Journal of biological chemistry, Vol. 279, Issue 34, pp. 36059-71, 2004 (PubMed).

Bache, Slagsvold, Cabezas et al.: "The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation." in: Molecular biology of the cell, Vol. 15, Issue 9, pp. 4337-46, 2004 (PubMed).

Dephoure, Zhou, Villuen et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).