Vacuolar Protein Sorting 37 Homolog A (S. Cerevisiae) (VPS37A) (C-Term) antibody

Details for Product No. ABIN351327
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Antigen
Synonyms fb08f03, fj42c03, zgc:73244, zgc:77637, wu:fb08f03, wu:fj42c03, HCRP1, PQBP2, SPG53, 2210018P21Rik, 4930592A21Rik, AW261445, D8Ertd531e
Epitope
C-Term
(2)
Reactivity
Mouse (Murine), Rat (Rattus), Human
(13), (7), (7), (1), (1), (1)
Host
Rabbit
(13)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(13), (8), (7), (2), (2), (2)
Pubmed 5 references available
Quantity 100 µL
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Catalog No. ABIN351327
454.67 $
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Immunogen A synthetic peptide from the c-terminal of human VPS37A conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
Specificity Specific for VPS37A.
Purification Whole serum
Alternative Name VPS37A
Background Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Subcellular location: Cytoplasm. Late endosome membrane, Peripheral membrane protein. Nucleus. Also known as: VPS37A, Hepatocellular carcinoma-related protein 1.
Research Area Signaling
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Xu, Liang, Wang et al.: "HCRP1, a novel gene that is downregulated in hepatocellular carcinoma, encodes a growth-inhibitory protein." in: Biochemical and biophysical research communications, Vol. 311, Issue 4, pp. 1057-66, 2003 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Stuchell, Garrus, Müller et al.: "The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding." in: The Journal of biological chemistry, Vol. 279, Issue 34, pp. 36059-71, 2004 (PubMed).

Bache, Slagsvold, Cabezas et al.: "The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation." in: Molecular biology of the cell, Vol. 15, Issue 9, pp. 4337-46, 2004 (PubMed).

Dephoure, Zhou, Villén et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).

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